Detailed information of TA system TA165217

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4578615..4579131
• Replicon: chromosome
• Accession: NZ_CP057313
• Organism: Klebsiella pneumoniae strain RHB30-C05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HVY73_RS22165
• Protein ID: WP_040170298.1
• Coordinates: 4578615..4578899 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: HVY73_RS22170
• Protein ID: WP_002886901.1
• Coordinates: 4578889..4579131 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY73_RS22140	4574098..4574406	-	309	WP_012737232.1	PTS sugar transporter subunit IIB	-
HVY73_RS22145	4574491..4574664	+	174	WP_004210630.1	hypothetical protein	-
HVY73_RS22150	4574667..4575410	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
HVY73_RS22155	4575767..4577905	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
HVY73_RS22160	4578147..4578611	+	465	WP_004192393.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HVY73_RS22165	4578615..4578899	-	285	WP_040170298.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HVY73_RS22170	4578889..4579131	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HVY73_RS22175	4579209..4581119	-	1911	WP_004152270.1	BglG family transcription antiterminator	-
HVY73_RS22180	4581142..4582296	-	1155	WP_004178372.1	lactonase family protein	-
HVY73_RS22185	4582363..4583103	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11186.06 Da
• Isoelectric Point: 10.3787

>T165217 WP_040170298.1 NZ_CP057313:c4578899-4578615 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGEMVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T165217 NZ_CP073768:736309-736605 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT165217 WP_002886901.1 NZ_CP057313:c4579131-4578889 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT165217 NZ_CP073768:736607-737002 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCACAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0