Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2556442..2558030 Replicon chromosome
Accession NZ_CP057313
Organism Klebsiella pneumoniae strain RHB30-C05

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HVY73_RS12585 Protein ID WP_096812286.1
Coordinates 2556442..2557764 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HVY73_RS12590 Protein ID WP_040216240.1
Coordinates 2557764..2558030 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY73_RS12570 2551499..2554000 + 2502 WP_117265386.1 fimbrial biogenesis outer membrane usher protein -
HVY73_RS12575 2553988..2554992 + 1005 WP_117050711.1 type 1 fimbrial protein -
HVY73_RS12580 2555133..2556425 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HVY73_RS12585 2556442..2557764 - 1323 WP_096812286.1 type II toxin-antitoxin system HipA family toxin Toxin
HVY73_RS12590 2557764..2558030 - 267 WP_040216240.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HVY73_RS12595 2558417..2558743 - 327 WP_002904788.1 hydroxyisourate hydrolase -
HVY73_RS12600 2558740..2559240 - 501 WP_032432595.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HVY73_RS12605 2559218..2560597 - 1380 WP_004184021.1 purine permease -
HVY73_RS12610 2560943..2562097 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HVY73_RS12615 2562078..2563001 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49095.41 Da        Isoelectric Point: 7.5366

>T165214 WP_096812286.1 NZ_CP057313:c2557764-2556442 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T165214 NZ_CP073768:205780-205887 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9959.39 Da        Isoelectric Point: 8.6103

>AT165214 WP_040216240.1 NZ_CP057313:c2558030-2557764 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DHNTDLDW

Download         Length: 267 bp

>AT165214 NZ_CP073768:c205732-205666 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References