Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 781154..781811 Replicon chromosome
Accession NZ_CP057313
Organism Klebsiella pneumoniae strain RHB30-C05

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HVY73_RS03885 Protein ID WP_002916310.1
Coordinates 781401..781811 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HVY73_RS03880 Protein ID WP_002916312.1
Coordinates 781154..781420 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY73_RS03855 776310..777743 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
HVY73_RS03860 777862..778590 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HVY73_RS03865 778640..778951 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HVY73_RS03870 779115..779774 + 660 WP_002916317.1 hemolysin III family protein -
HVY73_RS03875 779925..780908 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HVY73_RS03880 781154..781420 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HVY73_RS03885 781401..781811 + 411 WP_002916310.1 protein YgfX Toxin
HVY73_RS03890 781818..782339 - 522 WP_004144730.1 flavodoxin FldB -
HVY73_RS03895 782440..783336 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HVY73_RS03900 783359..784072 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVY73_RS03905 784078..785811 + 1734 WP_032105216.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T165203 WP_002916310.1 NZ_CP057313:781401-781811 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T165203 NZ_CP073764:c2550923-2550582 [Methylovirgula sp. HY1]
GTGGTCGGAGCGGGAGAACTGGTCTGGGTCGATTTCGATCCGGCCTTCGGGCATGAGCAGTCGGGGCGCCGTCCTGCACT
CGTCGTCTCCGACGGGGGCTATAATCAGGTGTCTTCGTTCATTCTCGTTTGTCCGATTACCCGCAATCCCAAGCCTTGGC
CGTTCAAAATCAGCCTTTCGGATATGTTCGTGGTAGACGGCCAAGTTCTGGTGGATCAGATCAAAGCAATCGACAAGCGC
TGCGTCGTTACGCCCGCCCTTGGCAAGGTCGACGATGAGGTGCTCTCTCAGATCCGCGGGCTTCTGGCTTCGCTTTTAGG
CTTTTCCGATGCGAACCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT165203 WP_002916312.1 NZ_CP057313:781154-781420 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT165203 NZ_CP073764:c2551233-2550958 [Methylovirgula sp. HY1]
ATGCGCGTCCAGATTTCAAAGTGGGGCAATTCGACCGCCCTTCGGCTTCCCAAGGCTCTCGTCGATGAACTCGGTCTCAG
GCTCGGCCAAGAGGTGGAGCTTGTGATTGAAGGACGGGAGGCGCGGCTGAGGCCCCTCAATGCGATCCCGCGCTATCGGA
TCGAAGATCTCGTTGCCGAGATGGGAAAGCTGGGGCGGAACAATGAACCCGCCTTGGAGGATTGGAGCGCTATCGAAGCA
CCTTGGCCAAACGACGCCCCGAAGCAAGGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References