Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4234336..4234961 Replicon chromosome
Accession NZ_CP057311
Organism Escherichia fergusonii strain RHB30-C07

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag HVY75_RS20325 Protein ID WP_000911329.1
Coordinates 4234563..4234961 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HVY75_RS20320 Protein ID WP_000450524.1
Coordinates 4234336..4234563 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY75_RS20295 4230138..4230608 - 471 WP_001068688.1 thioredoxin-dependent thiol peroxidase -
HVY75_RS20300 4230608..4231180 - 573 WP_000189057.1 glycine cleavage system transcriptional repressor -
HVY75_RS20305 4231327..4232205 + 879 WP_000494011.1 4-hydroxy-tetrahydrodipicolinate synthase -
HVY75_RS20310 4232222..4233256 + 1035 WP_002431657.1 outer membrane protein assembly factor BamC -
HVY75_RS20315 4233468..4234181 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HVY75_RS20320 4234336..4234563 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HVY75_RS20325 4234563..4234961 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
HVY75_RS20330 4235108..4235971 + 864 WP_001267498.1 neutral zinc metallopeptidase -
HVY75_RS20335 4235986..4238001 + 2016 WP_181203253.1 tRNA cytosine(34) acetyltransferase TmcA -
HVY75_RS20340 4238075..4238776 + 702 WP_105288162.1 esterase -
HVY75_RS20345 4238871..4239071 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T165198 WP_000911329.1 NZ_CP057311:4234563-4234961 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T165198 NZ_CP073754:2720159-2720518 [Methylomonas paludis]
ATGATTTTTTGGATTGACGCACAACTGCCTCCTAGGCTTGCAAACTGGTTGATTCAGACTTTTAATGAGGCCTACGCCTT
GCGTGATCTAAATTTACGCGATGCCGAAGACGAACAGATTTTTCATACTGCGCGCCGACCCGGTATCGTCATTATCAGCA
AAGACAGTGATTTCGTTGAAATGGTGTTACGTTTGGGCAGTCCTCCCCAATTACTCTGGGTCACCTGCGGCAATGTCACA
AATACCAGATTAGAAAACCTGTTGCTAAAAGTATTTCCACGAGCACAAGAATTGCTTTCTCAAGGTGAATCGATAGTTGA
GCTAACTGATCTGGATTCTAACCAATATAAAAACCATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT165198 WP_000450524.1 NZ_CP057311:4234336-4234563 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT165198 NZ_CP073754:2720007-2720162 [Methylomonas paludis]
ATGAGAATCCGGGTCAGTGATATTTTGCAAATGCTCGGCGAAGGCGTCAGTAGTGACGAAATTTTACTGGATTTTCCAGT
CCTTGAAATACAAGACATCCAAGCTTGCTTATTGTACGCGGCTCGCCGTGCAAATTTGGAAAGATTAGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References