Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3395371..3395893 Replicon chromosome
Accession NZ_CP057311
Organism Escherichia fergusonii strain RHB30-C07

Toxin (Protein)


Gene name relE Uniprot ID A0A7W3EN85
Locus tag HVY75_RS16365 Protein ID WP_046083069.1
Coordinates 3395603..3395893 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7LMQ7
Locus tag HVY75_RS16360 Protein ID WP_000212726.1
Coordinates 3395371..3395613 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY75_RS16340 3391220..3392593 + 1374 WP_001219809.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
HVY75_RS16345 3392744..3393295 - 552 WP_000166277.1 ribosome-associated protein -
HVY75_RS16350 3393389..3394741 + 1353 WP_001162171.1 metalloprotease PmbA -
HVY75_RS16355 3394794..3395180 + 387 WP_001232246.1 cytochrome b562 -
HVY75_RS16360 3395371..3395613 + 243 WP_000212726.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HVY75_RS16365 3395603..3395893 + 291 WP_046083069.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY75_RS16370 3395894..3396358 - 465 WP_001106232.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HVY75_RS16375 3396516..3398654 - 2139 WP_000187805.1 anaerobic ribonucleoside-triphosphate reductase -
HVY75_RS16380 3399048..3400703 - 1656 WP_181203089.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11323.22 Da        Isoelectric Point: 10.3007

>T165191 WP_046083069.1 NZ_CP057311:3395603-3395893 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVTVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRRVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T165191 NZ_CP073754:1088078-1088995 [Methylomonas paludis]
GTGAGCAAAGCAAACGTGGCGGCCTCAGTCCGGAGCAGATTGCTCAATCACGCCCGCGAGAAAAAACAGGATTTCAATCT
GGTACTAACCCGTTACACGATTGAGCGTTTGCTTTATCGAATCAGTATTTCTAAGCATGCAGACCAGTTTCTACTGAAAG
GAGCTCTCCTATTTGATCTCTGGTTTGACATTCCTCATCGTCCAACAAGAGATGCTGATTTCCTGGGATTTGGATCGGCC
GAACTGCCGAACATCGAAAGGGTCTTCAAGGAAGTCTGCATGATCGATACACCGGATGGTGTCGCGTTTCAATCCAACAC
AGTTCGGGCTGTCGAAATACGCAAGGAATCTCATTACGCCGGGGTGCGTGTAACCATGCTTGGAGTCATTGATGGTGCTC
GCTGTCATGTTCAGGTAGATATTGGCTTTGGAGATGCCGTAACCCCTGGACCAGAAAATGCTGAATACCCCGTTATTCTT
CGAGATTTCCCATCGCCGAAGCTAAGAGTTTATCCACGTTACACCGTGGTTGCGGAGAAATTCGAAGCACTTTCGTCCCT
GGGTATAGCAAACAGCCGGATGAAGGACTACTTCGATCTTTGGGTGCTGGCATGCCATACCGAATTTGACGGCGAAATTC
TCTGTCAAGCGGTTCGGGCGACGTTTGATCGCCGGAAGACAACACTATCGGAGCAAGTTCCTTTCGGTCTCACCCAAGCA
TTTGCAGAAGACCAGCAAAAGCAAGTGCAGTGGCAGGCGTTCCTTAGAAAAAACAAACTGGAGGCGCTCACGCTGGATGA
AGCTTTATCTAAATTAATAGTTTTCATGATGCCGGTAGTCCATGCAGCCAACACAAATAATGCATTTCAGTTTCGGTGGC
AAGCAGGCGGCCCCTGGTCGCCGGTAAATCTGAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9140.53 Da        Isoelectric Point: 5.1369

>AT165191 WP_000212726.1 NZ_CP057311:3395371-3395613 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRQLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT165191 NZ_CP073754:1087677-1088081 [Methylomonas paludis]
GTGGCGCGAAAGCATCCGCAGGCCATCGTCTGCCTACTTTCAGCGCTACGCTTCCACGATATCACAACACAGTCGCCATT
CGAAGTCTGGTTGGGCATTCCTAATAAAGCCCGCGCCCCCAGAATGGACTATCCGCCACTGCGAATCGTCCGGATTTCAG
GCGCCGCATTAATAGAAGGTGTGGAGGAACATAGGGTGGATGGTGTGCCGGTGCGCGTAACGAATATTGCCAGAACTGTA
GCCGATTGCTTTAAATACCGCAACAAGATCGGCCTGGAGGTGGCTCTCGAAGCACTGCAAGAGTCCGTGCGTGAAAAAGG
GGTTACTATGGATGATCTCTGGCGTTTTGCCACACTGTGCCGGGTTGCTAATGTGATGCGTCCCTATATGGAGAGTCTGC
CGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3EN85

Antitoxin

Source ID Structure
AlphaFold DB A0A7W3HXN7

References