Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1867368..1868022 Replicon chromosome
Accession NZ_CP057311
Organism Escherichia fergusonii strain RHB30-C07

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag HVY75_RS09195 Protein ID WP_000244781.1
Coordinates 1867368..1867775 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HVY75_RS09200 Protein ID WP_000354046.1
Coordinates 1867756..1868022 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY75_RS09175 1863325..1865058 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
HVY75_RS09180 1865064..1865774 - 711 WP_104917537.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVY75_RS09185 1865799..1866695 - 897 WP_000806645.1 site-specific tyrosine recombinase XerD -
HVY75_RS09190 1866807..1867328 + 522 WP_001055874.1 flavodoxin FldB -
HVY75_RS09195 1867368..1867775 - 408 WP_000244781.1 protein YgfX Toxin
HVY75_RS09200 1867756..1868022 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HVY75_RS09205 1868274..1869254 + 981 WP_181202810.1 tRNA-modifying protein YgfZ -
HVY75_RS09210 1869331..1869990 - 660 WP_000250283.1 hemolysin III family protein -
HVY75_RS09215 1870154..1870465 - 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
HVY75_RS09220 1870510..1871943 + 1434 WP_148047390.1 6-phospho-beta-glucosidase BglA -
HVY75_RS09225 1871991..1872884 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T165185 WP_000244781.1 NZ_CP057311:c1867775-1867368 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T165185 NZ_CP073745:964642-964896 [Bacterioplanoides sp. SCSIO 12839]
ATGAAACTGATCTTCTCCAGCAAAGCCTGGGAAAGTTACCTCTACTGGCAATCCACCGATAAGAAAATGCTGAAACGGAT
TAATGCATTAATCAAAGAGATTCAACGCACACCGTTTGAAGGTACTGGCAAGCCAGAGCCGTTAAAGCATGGCTTAATGG
GCTATTGGTCACGCCGGATTAATGATGAGCACCGGTTGGTTTATAAGGTGGAAGACGGTGCTGTGCTGATAGCGCAGCTT
AGGTATCACTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT165185 WP_000354046.1 NZ_CP057311:c1868022-1867756 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT165185 NZ_CP073745:964366-964620 [Bacterioplanoides sp. SCSIO 12839]
ATGGACGCTATCAGCTATACCGCTGCCCGCGCTAATTTGGCAAAAACGATGGAACAGGTCTGCAACGATCATGCTCCGGT
GATTATTACCCGCAAGAGTGAAGAACCTGTGGTGATGATGTCTCTGGAAGACTATCAGGCAATGCAGGAAACCACCTATT
TGTTACGCTCACCGGCCAACGCCCGGAATCTGCTGGAATCGATTGCTGAGTTAGAGAGTGGGCAGAGTGCAGAGCGTGTT
CTACTCGAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References