Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1588247..1588866 Replicon chromosome
Accession NZ_CP057311
Organism Escherichia fergusonii strain RHB30-C07

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HVY75_RS07800 Protein ID WP_001280991.1
Coordinates 1588648..1588866 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag HVY75_RS07795 Protein ID WP_000344803.1
Coordinates 1588247..1588621 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY75_RS07785 1583379..1584572 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVY75_RS07790 1584595..1587744 + 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
HVY75_RS07795 1588247..1588621 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
HVY75_RS07800 1588648..1588866 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HVY75_RS07805 1589361..1589831 + 471 WP_002431406.1 YlaC family protein -
HVY75_RS07810 1589970..1591520 + 1551 WP_181202748.1 EAL domain-containing protein -
HVY75_RS07815 1591562..1591915 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HVY75_RS07825 1592294..1592605 + 312 WP_000409907.1 MGMT family protein -
HVY75_RS07830 1592636..1593208 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T165184 WP_001280991.1 NZ_CP057311:1588648-1588866 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T165184 NZ_CP073745:964366-964620 [Bacterioplanoides sp. SCSIO 12839]
ATGGACGCTATCAGCTATACCGCTGCCCGCGCTAATTTGGCAAAAACGATGGAACAGGTCTGCAACGATCATGCTCCGGT
GATTATTACCCGCAAGAGTGAAGAACCTGTGGTGATGATGTCTCTGGAAGACTATCAGGCAATGCAGGAAACCACCTATT
TGTTACGCTCACCGGCCAACGCCCGGAATCTGCTGGAATCGATTGCTGAGTTAGAGAGTGGGCAGAGTGCAGAGCGTGTT
CTACTCGAAGATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT165184 WP_000344803.1 NZ_CP057311:1588247-1588621 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT165184 NZ_CP073745:964642-964896 [Bacterioplanoides sp. SCSIO 12839]
ATGAAACTGATCTTCTCCAGCAAAGCCTGGGAAAGTTACCTCTACTGGCAATCCACCGATAAGAAAATGCTGAAACGGAT
TAATGCATTAATCAAAGAGATTCAACGCACACCGTTTGAAGGTACTGGCAAGCCAGAGCCGTTAAAGCATGGCTTAATGG
GCTATTGGTCACGCCGGATTAATGATGAGCACCGGTTGGTTTATAAGGTGGAAGACGGTGCTGTGCTGATAGCGCAGCTT
AGGTATCACTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References