165145

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4307527..4308062 Replicon chromosome
Accession NZ_CP057258
Organism Citrobacter freundii strain RHB31-C16

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HVY90_RS20355 Protein ID WP_137399199.1
Coordinates 4307775..4308062 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4BKM9
Locus tag HVY90_RS20350 Protein ID WP_006688247.1
Coordinates 4307527..4307778 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY90_RS20320 4302540..4303388 + 849 WP_135912711.1 alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ -
HVY90_RS20325 4303385..4304143 + 759 WP_135912712.1 phosphonate C-P lyase system protein PhnK -
HVY90_RS20330 4304251..4304931 + 681 WP_117343579.1 phosphonate C-P lyase system protein PhnL -
HVY90_RS20335 4304928..4306064 + 1137 WP_096758663.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
HVY90_RS20340 4306067..4306612 + 546 WP_096758664.1 ribose 1,5-bisphosphokinase -
HVY90_RS20345 4306685..4307443 + 759 WP_181688554.1 phosphonate metabolism protein PhnP -
HVY90_RS20350 4307527..4307778 + 252 WP_006688247.1 plasmid stabilization protein Antitoxin
HVY90_RS20355 4307775..4308062 + 288 WP_137399199.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY90_RS20360 4308059..4308388 - 330 WP_181688555.1 hypothetical protein -
HVY90_RS20365 4308457..4310721 - 2265 WP_181688556.1 hybrid sensor histidine kinase/response regulator -
HVY90_RS20370 4310836..4312359 + 1524 WP_096758669.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11173.02 Da        Isoelectric Point: 10.2830

>T165145 WP_137399199.1 NZ_CP057258:4307775-4308062 [Citrobacter freundii]
MSYTVKFREDALKEWQKLDKTIQQQFAKELKKCGENPHVPSAKLRGIKDCYKIQLRTSRFRLVYQVIDDTLVIAVVAVGK
RERSEVYNLASERLR

Download         Length: 288 bp

>T165145 NZ_CP073718:4057814-4057966 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9215.53 Da        Isoelectric Point: 4.2965

>AT165145 WP_006688247.1 NZ_CP057258:4307527-4307778 [Citrobacter freundii]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Download         Length: 252 bp

>AT165145 NZ_CP073718:c4057765-4057708 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7X1BT32

References