165144

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4138487..4139003 Replicon chromosome
Accession NZ_CP057258
Organism Citrobacter freundii strain RHB31-C16

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HVY90_RS19540 Protein ID WP_181688517.1
Coordinates 4138487..4138771 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HVY90_RS19545 Protein ID WP_115259576.1
Coordinates 4138761..4139003 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY90_RS19525 4133688..4135340 + 1653 WP_181688516.1 alpha,alpha-phosphotrehalase -
HVY90_RS19530 4135759..4137897 + 2139 WP_115259574.1 anaerobic ribonucleoside-triphosphate reductase -
HVY90_RS19535 4138019..4138483 + 465 WP_096759476.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HVY90_RS19540 4138487..4138771 - 285 WP_181688517.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY90_RS19545 4138761..4139003 - 243 WP_115259576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HVY90_RS19550 4139081..4140994 - 1914 WP_181688518.1 BglG family transcription antiterminator -
HVY90_RS19555 4141016..4141756 - 741 WP_174360793.1 KDGP aldolase family protein -
HVY90_RS19560 4141753..4142871 - 1119 WP_146717607.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
HVY90_RS19565 4142855..4143988 - 1134 WP_181688519.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10896.75 Da        Isoelectric Point: 10.0482

>T165144 WP_181688517.1 NZ_CP057258:c4138771-4138487 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLVDVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T165144 NZ_CP073718:c3814024-3813626 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8947.32 Da        Isoelectric Point: 5.0490

>AT165144 WP_115259576.1 NZ_CP057258:c4139003-4138761 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLDKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT165144 NZ_CP073718:c3814320-3814027 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTTGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References