Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1826194..1826848 Replicon chromosome
Accession NZ_CP057256
Organism Escherichia fergusonii strain RHB31-C17

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag HVY91_RS08890 Protein ID WP_000244781.1
Coordinates 1826194..1826601 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HVY91_RS08895 Protein ID WP_000354046.1
Coordinates 1826582..1826848 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY91_RS08870 1822151..1823884 - 1734 WP_181670079.1 single-stranded-DNA-specific exonuclease RecJ -
HVY91_RS08875 1823890..1824600 - 711 WP_046076902.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVY91_RS08880 1824625..1825521 - 897 WP_000806645.1 site-specific tyrosine recombinase XerD -
HVY91_RS08885 1825633..1826154 + 522 WP_001055874.1 flavodoxin FldB -
HVY91_RS08890 1826194..1826601 - 408 WP_000244781.1 protein YgfX Toxin
HVY91_RS08895 1826582..1826848 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HVY91_RS08900 1827100..1828080 + 981 WP_181670080.1 tRNA-modifying protein YgfZ -
HVY91_RS08905 1828157..1828816 - 660 WP_000250283.1 hemolysin III family protein -
HVY91_RS08910 1828980..1829291 - 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
HVY91_RS08915 1829336..1830769 + 1434 WP_148047390.1 6-phospho-beta-glucosidase BglA -
HVY91_RS08920 1830817..1831710 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T165121 WP_000244781.1 NZ_CP057256:c1826601-1826194 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T165121 NZ_CP073715:2340433-2340717 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT165121 WP_000354046.1 NZ_CP057256:c1826848-1826582 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT165121 NZ_CP073715:2340195-2340443 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACTGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References