Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2027..2562 Replicon plasmid pRHB32-C05_3
Accession NZ_CP057245
Organism Escherichia fergusonii strain RHB32-C05

Toxin (Protein)


Gene name relE Uniprot ID T2HS21
Locus tag HVY96_RS23650 Protein ID WP_000222775.1
Coordinates 2275..2562 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T2HSA2
Locus tag HVY96_RS23645 Protein ID WP_001139207.1
Coordinates 2027..2278 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY96_RS23640 46..1077 + 1032 WP_000907867.1 replication initiation protein -
HVY96_RS23645 2027..2278 + 252 WP_001139207.1 plasmid stabilization protein Antitoxin
HVY96_RS23650 2275..2562 + 288 WP_000222775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY96_RS23655 2572..3117 + 546 WP_181576141.1 hypothetical protein -
HVY96_RS23660 4241..4354 + 114 Protein_4 IS91 family transposase -
HVY96_RS23665 4353..4640 - 288 WP_024195838.1 helix-turn-helix transcriptional regulator -
HVY96_RS23670 4640..4951 - 312 WP_181667538.1 type II toxin-antitoxin system RelE/ParE family toxin -
HVY96_RS23675 5690..7261 - 1572 WP_181576148.1 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..116001 116001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11142.17 Da        Isoelectric Point: 10.6261

>T165102 WP_000222775.1 NZ_CP057245:2275-2562 [Escherichia fergusonii]
MTYTVKFRDDALREWLKLDKSVQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

>T165102 NZ_CP073704:c1770909-1770493 [Burkholderia cenocepacia]
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGAGGGCGTTCTTCAG
GCAGGCCGAAGCGGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGCTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCCTGGCTGACGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCATTGATCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9216.45 Da        Isoelectric Point: 4.0927

>AT165102 WP_001139207.1 NZ_CP057245:2027-2278 [Escherichia fergusonii]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDAMDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT165102 NZ_CP073704:c1771132-1770896 [Burkholderia cenocepacia]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAATGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGTGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T2HS21

Antitoxin

Source ID Structure
AlphaFold DB A0A754EQ65

References