Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 137201..137726 Replicon plasmid pRHB32-C05_2
Accession NZ_CP057244
Organism Escherichia fergusonii strain RHB32-C05

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag HVY96_RS23580 Protein ID WP_001159871.1
Coordinates 137201..137506 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag HVY96_RS23585 Protein ID WP_000813634.1
Coordinates 137508..137726 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY96_RS23550 132468..133738 + 1271 Protein_133 translesion error-prone DNA polymerase V subunit UmuC -
HVY96_RS23555 133743..134135 - 393 WP_000340833.1 plasmid partitioning/stability family protein -
HVY96_RS23560 134140..135111 - 972 WP_097418955.1 plasmid segregation protein parM -
HVY96_RS23565 135340..135984 + 645 WP_000633911.1 AAA family ATPase -
HVY96_RS23570 135978..136253 + 276 WP_097418957.1 CopG family transcriptional regulator -
HVY96_RS23575 136391..137200 - 810 WP_097418958.1 site-specific integrase -
HVY96_RS23580 137201..137506 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
HVY96_RS23585 137508..137726 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HVY96_RS23590 138286..138516 + 231 WP_097309516.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HVY96_RS23595 138513..138929 + 417 WP_097418959.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - pefD / pefC / pefA 1..147532 147532


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T165100 WP_001159871.1 NZ_CP057244:c137506-137201 [Escherichia fergusonii]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T165100 NZ_CP073704:c894939-894622 [Burkholderia cenocepacia]
ATGCCCTACAGTCCTCCTGCATTCAGCATCCGGACCACCGACGTCTTCGACGCCTGGTTTGCCGGCCTGCCCGATCGCCT
CGCCAAACGCCGCATTCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCCCCCG
TCGTCGAAATGCGTATCGACCACGGCCCCGGCTATCGCGTCTATGACGTGAGGCGCGAAACGATATGGGTCATCCTGCTG
TGCGGCGGCGATCAATCGACGCAACTGGCCGACATCCGCGCCGCGCACGCAATGCTCGCGCACCTCGACATGGAGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.34 Da        Isoelectric Point: 4.7405

>AT165100 WP_000813634.1 NZ_CP057244:c137726-137508 [Escherichia fergusonii]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT165100 NZ_CP073704:c894618-894319 [Burkholderia cenocepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGTGCACGCGGCATGTCGC
AGGTCGCACGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTCGGCCTGCAATTGCACGGCGCCAAGGCTGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
PDB 3TCJ
PDB 2H3A
PDB 2ADN
PDB 2ADL
PDB 3HPW
PDB 2H3C
PDB 3G7Z
AlphaFold DB A0A829CQY2

References