Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3414847..3415466 Replicon chromosome
Accession NZ_CP057243
Organism Escherichia fergusonii strain RHB32-C05

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HVY96_RS16580 Protein ID WP_001280991.1
Coordinates 3415248..3415466 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag HVY96_RS16575 Protein ID WP_000344803.1
Coordinates 3414847..3415221 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY96_RS16565 3409979..3411172 + 1194 WP_181666680.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVY96_RS16570 3411195..3414344 + 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
HVY96_RS16575 3414847..3415221 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
HVY96_RS16580 3415248..3415466 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HVY96_RS16585 3415963..3416433 + 471 WP_002431406.1 YlaC family protein -
HVY96_RS16590 3416572..3418122 + 1551 WP_001260377.1 EAL domain-containing protein -
HVY96_RS16595 3418164..3418517 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HVY96_RS16605 3418896..3419207 + 312 WP_000409907.1 MGMT family protein -
HVY96_RS16610 3419238..3419810 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T165084 WP_001280991.1 NZ_CP057243:3415248-3415466 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T165084 NZ_CP073677:2748944-2749222 [Cupriavidus sp. KK10]
ATGATCCAGTCATTCAGATGTTCCGACACCGCTGAACTGTTCGCGGGCCGCTGCGTACCACGCTTCGGCAATATCCGCGC
CGTGGCCGAACGCAAGCTGCGGCTGCTGCAGAGTGCGTCGACGCTGGAGTTCCTGCGCTCCCCGCCGGGCAATCGCCTGC
AGTTACTGGCGGGCGACCGCAAAGGCCGCTACAGCATCCGCATCAACGAACAGTGGCGAATCTGCTTCATCTGGACCCAC
GACGGCCCGGCGGCCGTTGAGATCATCGACTATCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT165084 WP_000344803.1 NZ_CP057243:3414847-3415221 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT165084 NZ_CP073677:2749234-2749569 [Cupriavidus sp. KK10]
ATGGTTCGCTTCAAGGACGGCATGCGTCCCATCCACCCGGGCGAAATCCTGCGCGAGGATTTCCTGGTACCGCTCAACAT
GAGCGCCAACGCCCTGGCCCTCGCGCTGCGCGTGACCGCGGCGCGCATCAACGACATCGTCCGCGAGCAACGTGGCATCA
CGCCGGACACCGCCCTGCGCCTGGCGCGCTATTTTGGCGGCGATGCGCAGTCGTGGCTGAACTTGCAGCTGGACTATGAC
CTGAAGGTCGCGCAGCGCGACCACGGCGAGCGGATCATGGCGGAAGTGGCGCCGCGCAATGCGGCGGCGGCCGGTCAGCC
GGCTGCGGAAAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References