Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1183565..1184237 Replicon chromosome
Accession NZ_CP057243
Organism Escherichia fergusonii strain RHB32-C05

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HVY96_RS05835 Protein ID WP_137481439.1
Coordinates 1183565..1183885 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HVY96_RS05840 Protein ID WP_034173552.1
Coordinates 1183917..1184237 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY96_RS05810 1178907..1179755 + 849 WP_000847808.1 TIM barrel protein -
HVY96_RS05815 1179745..1180602 + 858 WP_181667197.1 oxidoreductase -
HVY96_RS05820 1180726..1181688 + 963 WP_000361628.1 sugar-binding transcriptional regulator -
HVY96_RS05825 1181955..1182287 + 333 WP_000522235.1 heavy metal-binding domain-containing protein -
HVY96_RS05830 1182360..1182602 - 243 WP_000497434.1 DinI family protein -
HVY96_RS05835 1183565..1183885 - 321 WP_137481439.1 TA system toxin CbtA family protein Toxin
HVY96_RS05840 1183917..1184237 - 321 WP_034173552.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HVY96_RS05845 1184255..1184476 - 222 WP_047955988.1 DUF987 family protein -
HVY96_RS05850 1184484..1184957 - 474 WP_021555650.1 DNA repair protein RadC -
HVY96_RS05855 1184990..1185808 - 819 WP_181667198.1 DUF945 domain-containing protein -
HVY96_RS05860 1186205..1186876 + 672 WP_181667199.1 inovirus Gp2 family protein -
HVY96_RS05865 1187191..1188603 + 1413 WP_181667200.1 DUF3987 domain-containing protein -
HVY96_RS05870 1188869..1189147 + 279 WP_181667201.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(8-105)

Antitoxin

Antitoxin CbeA

(4-102)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12009.67 Da        Isoelectric Point: 5.0356

>T165071 WP_137481439.1 NZ_CP057243:c1183885-1183565 [Escherichia fergusonii]
MHILSVPTTVPVSSRLSPVQVWQQLLTYLLEQHYGLTLNDTPFHDDAAIEEHIEAGITLADAVNFLVEKYELVRIDRKGF
SWQDQTPFLSATDILRARRATGIMST

Download         Length: 321 bp

>T165071 NZ_CP073674:144826-145227 [Burkholderia cenocepacia]
ATGCCGCGCTTCATGCTCGACACCAACATGTGTATCTATCTGATGAAAAATCAGCCTGAGCAGGTCGCGAGACGGTTTGC
GCAGTGCTACACGGGCGACGTCGTCATGTCGGCGATCACCTATGCGGAGCTCGAGTACGGCCTGACCGCTTGTGCGAATC
CCGCGCGGGAGCGCCGCCATCTCGCCGCATTGATCGAGGATATTCCCGTCGCGCCTTTCGACGCGGCGGCCGCGCAAGCG
TATGGCCCGGTTCGCGAGGCCACCCGCGAGCGGAAGAAGGATCACCTCGACAAACTGATTGCCGCGCATGCGGTGTCGCT
CGATGTCGTCCTTGTCACCAACAACGAGCGCGATTTCGTCAGCTATCCGGGATTGCGACTGGAGAACTGGCTGAACGACT
AG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12026.72 Da        Isoelectric Point: 6.7439

>AT165071 WP_034173552.1 NZ_CP057243:c1184237-1183917 [Escherichia fergusonii]
MKNSWGLKRDMTPCFGARLVQEGRRLHFLADRADISGAFNEEEALRLDQAFPLVMKQLELMLTTGELNPRHQHCVTLHHN
GLTCEADTLGSHGYVYIVIYPQTSSQ

Download         Length: 321 bp

>AT165071 NZ_CP073674:144590-144826 [Burkholderia cenocepacia]
ATGCATACCACGAGGGTATTCAGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCGGACCTTGCCTATGAGCGCAGCGA
TATCGAACTGGAAATTGAGCGCGTCGGTGACGAAATCCGCATTCGGCCGATGCGGCGGCCTTTGACCCAGGTACTGGCGA
AGTTCGCGAAATTCGGACCGGACTTCATGGCCGATGGGCGTGGCGACCACGAGCAGGCCGAACGTGAGGGTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References