Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 760382..760932 Replicon chromosome
Accession NZ_CP057243
Organism Escherichia fergusonii strain RHB32-C05

Toxin (Protein)


Gene name ccdB Uniprot ID F0JPU1
Locus tag HVY96_RS03755 Protein ID WP_001160963.1
Coordinates 760618..760932 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag HVY96_RS03750 Protein ID WP_000125566.1
Coordinates 760382..760615 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY96_RS03725 755454..755741 + 288 WP_000203741.1 ferredoxin-like protein FixX -
HVY96_RS03730 755800..757131 + 1332 WP_181667119.1 MFS transporter -
HVY96_RS03735 757239..757769 + 531 WP_181667120.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
HVY96_RS03740 757762..759624 + 1863 WP_181667121.1 glutathione-regulated potassium-efflux system protein KefC -
HVY96_RS03745 759817..760296 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
HVY96_RS03750 760382..760615 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HVY96_RS03755 760618..760932 + 315 WP_001160963.1 CcdB family protein Toxin
HVY96_RS03760 760929..761777 - 849 WP_000257179.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
HVY96_RS03765 761784..762161 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
HVY96_RS03770 762164..762985 - 822 WP_001065390.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HVY96_RS03775 762982..763971 - 990 WP_046076786.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HVY96_RS03780 763971..765257 - 1287 WP_181667122.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11722.70 Da        Isoelectric Point: 8.0666

>T165067 WP_001160963.1 NZ_CP057243:760618-760932 [Escherichia fergusonii]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSHIRPPERLNPILLLVDGKEYVLMTHETATVPVNTLG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T165067 NZ_CP073673:c819297-819046 [Burkholderia cenocepacia]
ATGCAACGGCTCCGCGAATTCCTGAGGCCGAAGAATCCCGATGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGTGGCTATGTGGCTCGGTACCGCCTCGATGGCGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCAGGGTACTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT165067 WP_000125566.1 NZ_CP057243:760382-760615 [Escherichia fergusonii]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT165067 NZ_CP073673:c819602-819324 [Burkholderia cenocepacia]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCACTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGTGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGTTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0JPU1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References