Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3514427..3514977 Replicon chromosome
Accession NZ_CP057238
Organism Escherichia fergusonii strain RHB32-C09

Toxin (Protein)


Gene name ccdB Uniprot ID F0JPU1
Locus tag HVZ00_RS16980 Protein ID WP_001160963.1
Coordinates 3514663..3514977 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag HVZ00_RS16975 Protein ID WP_000125566.1
Coordinates 3514427..3514660 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ00_RS16950 3509500..3509787 + 288 WP_000203741.1 ferredoxin-like protein FixX -
HVZ00_RS16955 3509846..3511177 + 1332 WP_074500872.1 MFS transporter -
HVZ00_RS16960 3511285..3511815 + 531 WP_000600701.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
HVZ00_RS16965 3511808..3513670 + 1863 WP_181668156.1 glutathione-regulated potassium-efflux system protein KefC -
HVZ00_RS16970 3513862..3514341 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
HVZ00_RS16975 3514427..3514660 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HVZ00_RS16980 3514663..3514977 + 315 WP_001160963.1 CcdB family protein Toxin
HVZ00_RS16985 3514974..3515822 - 849 WP_000257189.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
HVZ00_RS16990 3515829..3516206 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
HVZ00_RS16995 3516209..3517030 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HVZ00_RS17000 3517027..3518016 - 990 WP_181668157.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HVZ00_RS17005 3518016..3519302 - 1287 WP_181668158.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11722.70 Da        Isoelectric Point: 8.0666

>T165048 WP_001160963.1 NZ_CP057238:3514663-3514977 [Escherichia fergusonii]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSHIRPPERLNPILLLVDGKEYVLMTHETATVPVNTLG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T165048 NZ_CP073667:c487032-486733 [Burkholderia contaminans]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGATCATCTGAAAACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCGCGTGCACGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCCAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCTCGAAAGCGCACGCATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT165048 WP_000125566.1 NZ_CP057238:3514427-3514660 [Escherichia fergusonii]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT165048 NZ_CP073667:c487374-487036 [Burkholderia contaminans]
ATGGTTGACATACTGCAATCCATGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGGCGTCTTCGACACCTGGTT
TGCCGGCCTGCAGGATCGCGTCGCGAAGCGCCGCATCCAGGCACGCATCGACCGCCTCTCGATGGGCAATCCGGGCGACT
GGAAGTCCGCCGGCTCGCCGGTCGTCGAGATGCGGATCGACCACGGCCCGGGCTATCGCGTCTACTACGTCCGGCGCGGA
ACGATCTGGGTCATCCTGCTCTGCGGCGGCGATAAATCGTCGCAACAGGCCGACATCCGCGCCGCGCACGCGATGCTCGC
GCATCTCGACATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0JPU1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References