Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1548873..1549492 Replicon chromosome
Accession NZ_CP057238
Organism Escherichia fergusonii strain RHB32-C09

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HVZ00_RS07395 Protein ID WP_001280991.1
Coordinates 1549274..1549492 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag HVZ00_RS07390 Protein ID WP_000344803.1
Coordinates 1548873..1549247 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ00_RS07380 1544005..1545198 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVZ00_RS07385 1545221..1548370 + 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
HVZ00_RS07390 1548873..1549247 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
HVZ00_RS07395 1549274..1549492 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HVZ00_RS07400 1549989..1550459 + 471 WP_002431406.1 YlaC family protein -
HVZ00_RS07405 1550598..1552148 + 1551 WP_181667774.1 EAL domain-containing protein -
HVZ00_RS07410 1552190..1552543 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HVZ00_RS07420 1552922..1553233 + 312 WP_000409907.1 MGMT family protein -
HVZ00_RS07425 1553264..1553836 - 573 WP_124036461.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T165042 WP_001280991.1 NZ_CP057238:1549274-1549492 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T165042 NZ_CP073662:c32123-31821 [Pseudomonas sp. JS425]
ATGAAGACAATTAAACAAACCGCCACGTACAGGAACTGGGAACGCAAGCTGCGAGACAAGCAGGCCAAAGCCATCATCGC
TGCGCGAGTCTTCCGCGTTGCGCATGGTCTGCTTGGAGACGTTCAACCGGTGGGCCAAGGAATCAGCGAATTACGCATCC
ATCACGGCCCCGGCTACCGGGTGTATTTTCAGCAGCGAGGTAACCAGCTGGTCCTGTTGCTGTGTGGTGGAGACAAGAGC
AGCCAAGCGCGGGATATCGAAACCGCCAAAGCCTTGGCCAGCCAGTGGAGTGACGATGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT165042 WP_000344803.1 NZ_CP057238:1548873-1549247 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT165042 NZ_CP073662:c31824-31525 [Pseudomonas sp. JS425]
ATGAAAGAGCAATTTTACGACTACGACCCCGCTGATGCGTTGACTGATGCGGAGTCCATCGCGGTATTCATGGAGGACGC
ATTCGAAACGGGCGATGCGGCCTATATCGCAAAATGCCTGGGTGTCGTAGCCCGCGCCAAAGGGATGACCGCCCTTGCCA
ATGAATCTGGCCTTTCCCGCGAACACCTCTACCGGTCGTTCTCGGACAAGGGCAACCCGACTTTGAAAACCCTGCTGGCC
GTGATGCGTGCCGTTGGCCTGGATCTTACGACCCGCAAGCACGTTGAGCCGGTGCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References