Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 84572..85197 Replicon plasmid pRHB32-C22_2
Accession NZ_CP057221
Organism Escherichia fergusonii strain RHB32-C22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HVZ07_RS22455 Protein ID WP_097418975.1
Coordinates 84799..85197 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag HVZ07_RS22450 Protein ID WP_000450532.1
Coordinates 84572..84799 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ07_RS22450 84572..84799 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
HVZ07_RS22455 84799..85197 + 399 WP_097418975.1 tRNA(fMet)-specific endonuclease VapC Toxin
HVZ07_RS22460 85206..87359 - 2154 WP_175616535.1 type IV conjugative transfer system coupling protein TraD -
HVZ07_RS22465 87612..88343 - 732 WP_000850424.1 complement resistance protein TraT -
HVZ07_RS22470 88375..88872 - 498 WP_038341570.1 surface exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - hlyD / hlyB / hlyC 1..147240 147240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14887.13 Da        Isoelectric Point: 7.8604

>T164996 WP_097418975.1 NZ_CP057221:84799-85197 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPASVRDRFNLNQGRMCISSVTLMELIYGAEKSQMPERNLDVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

>T164996 NZ_CP073627:1886343-1886445 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT164996 WP_000450532.1 NZ_CP057221:84572-84799 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp

>AT164996 NZ_CP073627:c1886452-1886307 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References