Detailed information of TA system TA164990

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3631267..3631921
• Replicon: chromosome
• Accession: NZ_CP057220
• Organism: Escherichia fergusonii strain RHB32-C22

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: F0JPE9
• Locus tag: HVZ07_RS17460
• Protein ID: WP_000244774.1
• Coordinates: 3631267..3631674 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HVZ07_RS17465
• Protein ID: WP_181667837.1
• Coordinates: 3631655..3631921 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ07_RS17440	3627224..3628957	-	1734	WP_000813234.1	single-stranded-DNA-specific exonuclease RecJ	-
HVZ07_RS17445	3628963..3629673	-	711	WP_046076902.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HVZ07_RS17450	3629698..3630594	-	897	WP_000806645.1	site-specific tyrosine recombinase XerD	-
HVZ07_RS17455	3630706..3631227	+	522	WP_001055874.1	flavodoxin FldB	-
HVZ07_RS17460	3631267..3631674	-	408	WP_000244774.1	protein YgfX	Toxin
HVZ07_RS17465	3631655..3631921	-	267	WP_181667837.1	FAD assembly factor SdhE	Antitoxin
HVZ07_RS17470	3632173..3633153	+	981	WP_181667838.1	tRNA-modifying protein YgfZ	-
HVZ07_RS17475	3633180..3634478	+	1299	WP_181667839.1	hypothetical protein	-
HVZ07_RS17480	3634475..3634942	+	468	WP_181667840.1	hypothetical protein	-
HVZ07_RS17485	3634973..3635632	-	660	WP_000250283.1	hemolysin III family protein	-
HVZ07_RS17490	3635796..3636107	-	312	WP_001182952.1	N(4)-acetylcytidine aminohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16078.05 Da
• Isoelectric Point: 11.2511

>T164990 WP_000244774.1 NZ_CP057220:c3631674-3631267 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T164990 NZ_CP073624:c4399580-4399407 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10531.16 Da
• Isoelectric Point: 5.6375

>AT164990 WP_181667837.1 NZ_CP057220:c3631921-3631655 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSVDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT164990 NZ_CP073624:c4399904-4399608 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A0L6ZX35