Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3301162..3301781 Replicon chromosome
Accession NZ_CP057220
Organism Escherichia fergusonii strain RHB32-C22

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HVZ07_RS15750 Protein ID WP_001280991.1
Coordinates 3301563..3301781 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag HVZ07_RS15745 Protein ID WP_000344803.1
Coordinates 3301162..3301536 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ07_RS15735 3296294..3297487 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVZ07_RS15740 3297510..3300659 + 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
HVZ07_RS15745 3301162..3301536 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
HVZ07_RS15750 3301563..3301781 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HVZ07_RS15755 3302278..3302748 + 471 WP_002431406.1 YlaC family protein -
HVZ07_RS15760 3302887..3304437 + 1551 WP_181667774.1 EAL domain-containing protein -
HVZ07_RS15765 3304479..3304832 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HVZ07_RS15775 3305211..3305522 + 312 WP_000409907.1 MGMT family protein -
HVZ07_RS15780 3305553..3306125 - 573 WP_124036461.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T164989 WP_001280991.1 NZ_CP057220:3301563-3301781 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T164989 NZ_CP073624:c4264473-4264123 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT164989 WP_000344803.1 NZ_CP057220:3301162-3301536 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT164989 NZ_CP073624:c4264718-4264467 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References