Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 81185..81828 Replicon plasmid pRHB33-C04_2
Accession NZ_CP057216
Organism Escherichia fergusonii strain RHB33-C04

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HVZ08_RS23295 Protein ID WP_097418959.1
Coordinates 81185..81601 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag HVZ08_RS23300 Protein ID WP_097309516.1
Coordinates 81598..81828 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ08_RS23285 76740..76997 - 258 WP_000343099.1 hypothetical protein -
HVZ08_RS23290 77346..81140 + 3795 WP_175616550.1 pcar -
HVZ08_RS23295 81185..81601 - 417 WP_097418959.1 type II toxin-antitoxin system VapC family toxin Toxin
HVZ08_RS23300 81598..81828 - 231 WP_097309516.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HVZ08_RS23305 82064..82564 + 501 WP_000528932.1 hypothetical protein -
HVZ08_RS23310 82577..83350 + 774 WP_000905949.1 hypothetical protein -
HVZ08_RS23315 83517..84650 + 1134 WP_181576151.1 DUF3800 domain-containing protein -
HVZ08_RS23320 84684..85196 - 513 WP_000151784.1 hypothetical protein -
HVZ08_RS23325 85427..85504 + 78 Protein_79 helix-turn-helix domain-containing protein -
HVZ08_RS23330 85748..86092 + 345 WP_001559862.1 type II toxin-antitoxin system PrlF family antitoxin -
HVZ08_RS23335 86115..86609 + 495 WP_024195926.1 type II toxin-antitoxin system YhaV family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - pefA / pefC / pefD 1..160081 160081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14948.29 Da        Isoelectric Point: 6.7113

>T164961 WP_097418959.1 NZ_CP057216:c81601-81185 [Escherichia fergusonii]
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFERVPGLVLEDWAG

Download         Length: 417 bp

>T164961 NZ_CP073621:4196718-4196972 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTATAGAGGAACACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8811.02 Da        Isoelectric Point: 4.6282

>AT164961 WP_097309516.1 NZ_CP057216:c81828-81598 [Escherichia fergusonii]
MRTVSIFKNGNNRAIRLPRELDFEGVSELEIIREGNSIILRPVRPTWSSFLELEKADPGFMTEREDVVCDEGRFNL

Download         Length: 231 bp

>AT164961 NZ_CP073621:4196470-4196721 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCACCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References