Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3660599..3661253 Replicon chromosome
Accession NZ_CP057215
Organism Escherichia fergusonii strain RHB33-C04

Toxin (Protein)


Gene name cptA Uniprot ID F0JPE9
Locus tag HVZ08_RS17695 Protein ID WP_000244774.1
Coordinates 3660599..3661006 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HVZ08_RS17700 Protein ID WP_000354046.1
Coordinates 3660987..3661253 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ08_RS17675 3656556..3658289 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
HVZ08_RS17680 3658295..3659005 - 711 WP_104917537.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVZ08_RS17685 3659030..3659926 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HVZ08_RS17690 3660038..3660559 + 522 WP_001055874.1 flavodoxin FldB -
HVZ08_RS17695 3660599..3661006 - 408 WP_000244774.1 protein YgfX Toxin
HVZ08_RS17700 3660987..3661253 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HVZ08_RS17705 3661505..3662485 + 981 WP_181666750.1 tRNA-modifying protein YgfZ -
HVZ08_RS17710 3662562..3663221 - 660 WP_000250283.1 hemolysin III family protein -
HVZ08_RS17715 3663385..3663696 - 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
HVZ08_RS17720 3663741..3665174 + 1434 WP_148047390.1 6-phospho-beta-glucosidase BglA -
HVZ08_RS17725 3665222..3666115 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16078.05 Da        Isoelectric Point: 11.2511

>T164954 WP_000244774.1 NZ_CP057215:c3661006-3660599 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T164954 NZ_CP073621:2535283-2535390 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT164954 WP_000354046.1 NZ_CP057215:c3661253-3660987 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164954 NZ_CP073621:c2535234-2535171 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L6ZX35

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References