Detailed information of TA system TA164941

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1176227..1176899
• Replicon: chromosome
• Accession: NZ_CP057215
• Organism: Escherichia fergusonii strain RHB33-C04

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HVZ08_RS05800
• Protein ID: WP_137481439.1
• Coordinates: 1176227..1176547 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HVZ08_RS05805
• Protein ID: WP_034173552.1
• Coordinates: 1176579..1176899 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ08_RS05775	1171569..1172417	+	849	WP_000847808.1	TIM barrel protein	-
HVZ08_RS05780	1172407..1173264	+	858	WP_181667197.1	oxidoreductase	-
HVZ08_RS05785	1173388..1174350	+	963	WP_000361628.1	sugar-binding transcriptional regulator	-
HVZ08_RS05790	1174617..1174949	+	333	WP_000522235.1	heavy metal-binding domain-containing protein	-
HVZ08_RS05795	1175022..1175264	-	243	WP_000497434.1	DinI family protein	-
HVZ08_RS05800	1176227..1176547	-	321	WP_137481439.1	TA system toxin CbtA family protein	Toxin
HVZ08_RS05805	1176579..1176899	-	321	WP_034173552.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HVZ08_RS05810	1176917..1177138	-	222	WP_047955988.1	DUF987 family protein	-
HVZ08_RS05815	1177146..1177619	-	474	WP_021555650.1	DNA repair protein RadC	-
HVZ08_RS05820	1177652..1178470	-	819	WP_181667198.1	DUF945 domain-containing protein	-
HVZ08_RS05825	1178867..1179538	+	672	WP_181667199.1	inovirus Gp2 family protein	-
HVZ08_RS05830	1179853..1181265	+	1413	WP_181667200.1	DUF3987 domain-containing protein	-
HVZ08_RS05835	1181531..1181809	+	279	WP_181667201.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-105)

Antitoxin

• Antitoxin CbeA (4-102)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12009.67 Da
• Isoelectric Point: 5.0356

>T164941 WP_137481439.1 NZ_CP057215:c1176547-1176227 [Escherichia fergusonii]
MHILSVPTTVPVSSRLSPVQVWQQLLTYLLEQHYGLTLNDTPFHDDAAIEEHIEAGITLADAVNFLVEKYELVRIDRKGF
SWQDQTPFLSATDILRARRATGIMST

Nucleotide

• Length: 321 bp

>T164941 NZ_CP073621:148620-148727 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12026.72 Da
• Isoelectric Point: 6.7439

>AT164941 WP_034173552.1 NZ_CP057215:c1176899-1176579 [Escherichia fergusonii]
MKNSWGLKRDMTPCFGARLVQEGRRLHFLADRADISGAFNEEEALRLDQAFPLVMKQLELMLTTGELNPRHQHCVTLHHN
GLTCEADTLGSHGYVYIVIYPQTSSQ

Nucleotide

• Length: 321 bp

>AT164941 NZ_CP073621:c148570-148507 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT