Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 533514..534036 Replicon chromosome
Accession NZ_CP057215
Organism Escherichia fergusonii strain RHB33-C04

Toxin (Protein)


Gene name relE Uniprot ID F0JQI6
Locus tag HVZ08_RS02525 Protein ID WP_001105434.1
Coordinates 533746..534036 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag HVZ08_RS02520 Protein ID WP_000212715.1
Coordinates 533514..533756 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ08_RS02500 529431..530804 + 1374 WP_001219783.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
HVZ08_RS02505 530887..531438 - 552 WP_000166270.1 ribosome-associated protein -
HVZ08_RS02510 531532..532884 + 1353 WP_001162171.1 metalloprotease PmbA -
HVZ08_RS02515 532937..533323 + 387 WP_001232246.1 cytochrome b562 -
HVZ08_RS02520 533514..533756 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HVZ08_RS02525 533746..534036 + 291 WP_001105434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVZ08_RS02530 534037..534501 - 465 WP_001106232.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HVZ08_RS02535 534686..536824 - 2139 WP_000187805.1 anaerobic ribonucleoside-triphosphate reductase -
HVZ08_RS02540 537218..538873 - 1656 WP_181667077.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11323.22 Da        Isoelectric Point: 10.3007

>T164933 WP_001105434.1 NZ_CP057215:533746-534036 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVTVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRRVYQVNDKELIVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T164933 NZ_CP073589:3730448-3730621 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT164933 WP_000212715.1 NZ_CP057215:533514-533756 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT164933 NZ_CP073589:3730124-3730420 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0JQI6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References