Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3660554..3661208 Replicon chromosome
Accession NZ_CP057210
Organism Escherichia fergusonii strain RHB33-C07

Toxin (Protein)


Gene name cptA Uniprot ID F0JPE9
Locus tag HVZ09_RS17725 Protein ID WP_000244774.1
Coordinates 3660554..3660961 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HVZ09_RS17730 Protein ID WP_000354046.1
Coordinates 3660942..3661208 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ09_RS17705 3656511..3658244 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
HVZ09_RS17710 3658250..3658960 - 711 WP_104917537.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVZ09_RS17715 3658985..3659881 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HVZ09_RS17720 3659993..3660514 + 522 WP_001055874.1 flavodoxin FldB -
HVZ09_RS17725 3660554..3660961 - 408 WP_000244774.1 protein YgfX Toxin
HVZ09_RS17730 3660942..3661208 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HVZ09_RS17735 3661460..3662440 + 981 WP_181666750.1 tRNA-modifying protein YgfZ -
HVZ09_RS17740 3662517..3663176 - 660 WP_000250283.1 hemolysin III family protein -
HVZ09_RS17745 3663340..3663651 - 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
HVZ09_RS17750 3663696..3665129 + 1434 WP_148047390.1 6-phospho-beta-glucosidase BglA -
HVZ09_RS17755 3665177..3666070 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16078.05 Da        Isoelectric Point: 11.2511

>T164913 WP_000244774.1 NZ_CP057210:c3660961-3660554 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T164913 NZ_CP073587:1199823-1200077 [Shewanella yunxiaonensis]
GTGAAAATCGTATCTTTTACTGAAGCTAGAAATGGTCTCAAAGCTGTTTTAGACGGTGTAGTTAATGATGCTGATACTAC
AGTTATTACGCGCCGCGATTCTGAAGATGCAGTGGTTATGTCTTTAGATTATTACAATAGCCTTATGGAGACAGTTCACT
TACTACGTTCTCCTCAAAATGCTGAACACCTAAACCGTTCGATAGCACAGTACCGAGCTGGTAAAACAACAGCACGTGAG
TTAATTGATGAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT164913 WP_000354046.1 NZ_CP057210:c3661208-3660942 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164913 NZ_CP073587:1200070-1200339 [Shewanella yunxiaonensis]
ATGAGTAGTCGTCAACATATACTGTCCTGGACTGATGACGCTTGGGAGGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAATAAACTTATTAATGATGTTAAGCGCTCTCCGTTTGAGGGGATTGGTAAACCTGAACCTTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTATTGATGACACCAATAGGCTTGTTTACGTAGTCGATGATCAAGCTATA
ACGATAATTTCTTGTCGTTATCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L6ZX35

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References