Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3374239..3374858 Replicon chromosome
Accession NZ_CP057210
Organism Escherichia fergusonii strain RHB33-C07

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HVZ09_RS16280 Protein ID WP_001280991.1
Coordinates 3374640..3374858 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag HVZ09_RS16275 Protein ID WP_000344803.1
Coordinates 3374239..3374613 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ09_RS16265 3369371..3370564 + 1194 WP_181666680.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVZ09_RS16270 3370587..3373736 + 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
HVZ09_RS16275 3374239..3374613 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
HVZ09_RS16280 3374640..3374858 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HVZ09_RS16285 3375355..3375825 + 471 WP_002431406.1 YlaC family protein -
HVZ09_RS16290 3375964..3377514 + 1551 WP_001260377.1 EAL domain-containing protein -
HVZ09_RS16295 3377556..3377909 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HVZ09_RS16305 3378288..3378599 + 312 WP_181666681.1 MGMT family protein -
HVZ09_RS16310 3378630..3379202 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T164911 WP_001280991.1 NZ_CP057210:3374640-3374858 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T164911 NZ_CP073579:c912522-911200 [Photobacterium sp. GJ3]
ATGGTAAGGCAGCTTCGGGTGCTGATGAATGGTTTGAATGTGGGTGTATTTACAAAAGAAGTCACTGGCGCACACACTTT
TCAATACGATGAAGCGTGGATTCATTCAAAAAAGCGTCGTGCAATCTCACTTTCTCTGCCATTAAGAAAAGCCCGCTTTA
CTGGCGATGAGGTGATCAATTTTTTTGATAACCTGTTGCCGGATAACCCTCAGGTCAGGGAGCGAATCGTTGCCAGGTAT
GATGCAAAAACAAAGCAGCCATTTGACTTGCTGGAAAAAATTGGCCGTGACAGTGTGGGTGCAATTACTCTGATTCCTGA
AGGTCAGCCAATCCCTGACTTCAAAAAAATCAGTGCAACGGAATTAACTGCCGCACGGCTGGAACACGTGTTAAATGCTT
ATACAGACAATATCCCCTTGGGTATGGTCGACGGGAATGACGACTTTCGGATTTCGATTGCCGGTGCTCAGGAAAAAACA
GCCTTACTGAAGCGGCATGATCGCTGGTATATCCCGAATGGATTAACACCCACCACGCATATTATTAAACTGCCAATTGG
GGAAATCAGAACACAAAGCAGTGTTTTGGACCTGACAACCAGCGTCGATAATGAATTGATCTGCATGCGCCTTTCCAGAG
CGTTTGGTTTACCCACAGCAAGCTGTGACGTGCTTCATGCCGGGAAGGTCAGAGCATTAGCCGTTGAGCGCTTCGACAGG
CGATATGCCCAGAAAGAAGACTGGATTGTACGGTTACCACAGGAAGATTTTTGTCAGGTATCGGGTATTTCACCTGCGAA
AAAGTACGAGGTAGATGGTGGCATTGGAATTGAGGGGATTATGAATCATCTGCTCGGTTCAGAAATTGCCGGAGAAGACA
GGCGTACCTTTATGAAAGCTCAGGTGCTGTTTTTTGTGCTGGCAGCCATTGATGGCCATGCCAAAAACTTTTCTTTGTTT
CTTCAGCCCAACGGGAAATACCGTCTGACACCCCTATATGACATCATTTCTGCATATCCGATGATGGGGGGAAAAGGGAT
CCACGAAAGGAAAATAAAACTGGCGATGGGTTTGAAGGCGAGCACTGGCTATAAACGGCATTGGTATCAAATTCAGGCCC
GGCACTTTATGAACACCGCAAGACTTGTGAAATATTCTTCTGAGTCGATGAGGGAAATTTTAGAGGAATTTCAAGGGAGT
TATATGTCGGCGGTCGATCAGGTTGGGAATCAGTTGCCTCAAGACATTGATGAGAATGTGAGAGATAAAATATTCGAAGG
GATTGTGAAATCCATGAGAAGGTTAACCCTCAATCCAGCATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT164911 WP_000344803.1 NZ_CP057210:3374239-3374613 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT164911 NZ_CP073579:c912767-912516 [Photobacterium sp. GJ3]
GTGCTGATCACATCACCAAAACAACTCGCCACTCATCTCAAAGATGAAAGGAAGTCCAAAAGATTGTCTCAGGAAAAAGT
CGCTGATCCCGTTGGGCTGAAGCAGGACACCGTCTCAAAATTTGAGATTAATCCTGAAACAACCAGTATTGGAACATTAT
TCCGGATTTTATCTTCACTGGATCTCGAGCTGCATTTACAACCCAAAGGGAAAAGTGGCGAGCCGAGTGATGAGGATGAT
GAGCTATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References