Detailed information of TA system TA164891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4547830..4548458
• Replicon: chromosome
• Accession: NZ_CP057150
• Organism: Citrobacter sp. RHB35-C17

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A7L6UNG2
• Locus tag: HVZ37_RS21595
• Protein ID: WP_044328134.1
• Coordinates: 4547830..4548216 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HVZ37_RS21600
• Protein ID: WP_161215612.1
• Coordinates: 4548216..4548458 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ37_RS21575	4543183..4544520	+	1338	WP_155985523.1	VWA domain-containing protein	-
HVZ37_RS21580	4544538..4546034	+	1497	WP_181627960.1	HAMP domain-containing histidine kinase	-
HVZ37_RS21585	4546039..4546725	+	687	WP_042998867.1	response regulator transcription factor	-
HVZ37_RS21590	4546870..4547799	+	930	WP_042998866.1	formate dehydrogenase accessory protein FdhE	-
HVZ37_RS21595	4547830..4548216	-	387	WP_044328134.1	type II toxin-antitoxin system VapC family toxin	Toxin
HVZ37_RS21600	4548216..4548458	-	243	WP_161215612.1	ribbon-helix-helix domain-containing protein	Antitoxin
HVZ37_RS21605	4548666..4549592	+	927	WP_181627961.1	alpha/beta hydrolase	-
HVZ37_RS21610	4549608..4550549	-	942	WP_042998862.1	fatty acid biosynthesis protein FabY	-
HVZ37_RS21615	4550594..4551031	-	438	WP_044265155.1	D-tyrosyl-tRNA(Tyr) deacylase	-
HVZ37_RS21620	4551028..4551900	-	873	WP_044257165.1	virulence factor BrkB family protein	-
HVZ37_RS21625	4551894..4552493	-	600	WP_044265152.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-112)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14394.61 Da
• Isoelectric Point: 8.4794

>T164891 WP_044328134.1 NZ_CP057150:c4548216-4547830 [Citrobacter sp. RHB35-C17]
MQKGPVLFDTNILIDLFSGHQEAQHVLEAYPPQNAISLVTWMEVMVGAKKYHQEYRTRVALSAFNIIGVSQEIAERSVNL
RQEYGMKLPDAIILATAQIHRFALVTRNTRDFAGIPGVITPYQLQAGR

Nucleotide

• Length: 387 bp

>T164891 NZ_CP073377:395844-396329 [Klebsiella sp. P1927]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9335.53 Da
• Isoelectric Point: 4.2075

>AT164891 WP_161215612.1 NZ_CP057150:c4548458-4548216 [Citrobacter sp. RHB35-C17]
IMAGMDMGRILLDLSDEVIKRLDDLKQQRNLPRAELLREAVEQYLERQGQAETTISNALGLWQGCEEDGVEYQRTLREEW

Nucleotide

• Length: 243 bp

>AT164891 NZ_CP073377:395554-395847 [Klebsiella sp. P1927]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Toxin

• AlphaFold DB: A0A7L6UNG2