Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3908816..3909470 Replicon chromosome
Accession NZ_CP057150
Organism Citrobacter sp. RHB35-C17

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Q8D714
Locus tag HVZ37_RS18615 Protein ID WP_044254016.1
Coordinates 3908816..3909223 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag HVZ37_RS18620 Protein ID WP_042322123.1
Coordinates 3909204..3909470 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ37_RS18595 3904721..3906454 - 1734 WP_181627866.1 single-stranded-DNA-specific exonuclease RecJ -
HVZ37_RS18600 3906460..3907173 - 714 WP_054176762.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVZ37_RS18605 3907197..3908093 - 897 WP_042999367.1 site-specific tyrosine recombinase XerD -
HVZ37_RS18610 3908194..3908715 + 522 WP_181627867.1 flavodoxin FldB -
HVZ37_RS18615 3908816..3909223 - 408 WP_044254016.1 protein YgfX Toxin
HVZ37_RS18620 3909204..3909470 - 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
HVZ37_RS18625 3909727..3910707 + 981 WP_181627868.1 tRNA-modifying protein YgfZ -
HVZ37_RS18630 3910788..3911447 - 660 WP_044264418.1 hemolysin III family protein -
HVZ37_RS18635 3911610..3911921 - 312 WP_042999362.1 N(4)-acetylcytidine aminohydrolase -
HVZ37_RS18640 3911974..3912702 + 729 WP_109739479.1 MurR/RpiR family transcriptional regulator -
HVZ37_RS18645 3912822..3914255 + 1434 WP_044254006.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15863.86 Da        Isoelectric Point: 11.6030

>T164889 WP_044254016.1 NZ_CP057150:c3909223-3908816 [Citrobacter sp. RHB35-C17]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDKAEWRDLRRLMMQPSTQG

Download         Length: 408 bp

>T164889 NZ_CP073376:27491-27640 [Klebsiella sp. P1954]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT164889 WP_042322123.1 NZ_CP057150:c3909470-3909204 [Citrobacter sp. RHB35-C17]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT164889 NZ_CP073376:c27446-27387 [Klebsiella sp. P1954]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8D714

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References