Detailed information of TA system TA164888

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 3570724..3571457
• Replicon: chromosome
• Accession: NZ_CP057150
• Organism: Citrobacter sp. RHB35-C17

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: HVZ37_RS17070
• Protein ID: WP_181627785.1
• Coordinates: 3571128..3571457 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HVZ37_RS17065
• Protein ID: WP_181627784.1
• Coordinates: 3570724..3571089 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ37_RS17020	3565943..3566656	+	714	WP_000075763.1	sporulation transcriptional regulator SpoIIID	-
HVZ37_RS17025	3566653..3567288	+	636	WP_047667669.1	hypothetical protein	-
HVZ37_RS17030	3567327..3567782	+	456	WP_181627780.1	hypothetical protein	-
HVZ37_RS17035	3567779..3568228	+	450	WP_181627781.1	hypothetical protein	-
HVZ37_RS17040	3568300..3568531	+	232	Protein_3336	DUF905 domain-containing protein	-
HVZ37_RS17045	3568630..3569451	+	822	WP_087835510.1	DUF945 domain-containing protein	-
HVZ37_RS17050	3569482..3569925	+	444	WP_181627782.1	antirestriction protein	-
HVZ37_RS17055	3569938..3570480	+	543	WP_101427267.1	DNA repair protein RadC	-
HVZ37_RS17060	3570477..3570698	+	222	WP_181627783.1	DUF987 domain-containing protein	-
HVZ37_RS17065	3570724..3571089	+	366	WP_181627784.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HVZ37_RS17070	3571128..3571457	+	330	WP_181627785.1	TA system toxin CbtA family protein	Toxin
HVZ37_RS17075	3571825..3573071	+	1247	Protein_3343	tyrosine-type recombinase/integrase	-
HVZ37_RS17080	3573073..3573717	+	645	WP_015958821.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3553628..3586777	33149

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12353.04 Da
• Isoelectric Point: 7.3216

>T164888 WP_181627785.1 NZ_CP057150:3571128-3571457 [Citrobacter sp. RHB35-C17]
MQTLSSHPTQAAQPCLSPIEIWQCLLTHLLSQHYGLTLNDTPFSNETTIREHIDAGVSLSDAVNFLVERYGLVRIDRKGF
SWQEQTPYISVVDILRARRSTGLQKTNVK

Nucleotide

• Length: 330 bp

>T164888 NZ_CP073374:70846-71262 [Klebsiella sp. P1954]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13515.30 Da
• Isoelectric Point: 5.9576

>AT164888 WP_181627784.1 NZ_CP057150:3570724-3571089 [Citrobacter sp. RHB35-C17]
MNNHSESGTKPESPACQLWGLKRAITPCFGARLVQEGNRVHFLADRAGFNGAFSDNDALRLDQAFPLMLKQLELMLISSE
LNPRYQHCVTLYHNGLTCEADTLGSCGYVYIAIYPEQTEPH

Nucleotide

• Length: 366 bp

>AT164888 NZ_CP073374:70619-70849 [Klebsiella sp. P1954]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA