Detailed information of TA system TA164878

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1832606..1833425
• Replicon: chromosome
• Accession: NZ_CP057150
• Organism: Citrobacter sp. RHB35-C17

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A3S5G4N2
• Locus tag: HVZ37_RS08595
• Protein ID: WP_043001077.1
• Coordinates: 1832606..1832863 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HVZ37_RS08600
• Protein ID: WP_044258114.1
• Coordinates: 1832874..1833425 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ37_RS08570	1828411..1829316	-	906	WP_043001082.1	dihydrodipicolinate synthase family protein	-
HVZ37_RS08575	1829321..1830109	-	789	WP_181628334.1	IclR family transcriptional regulator	-
HVZ37_RS08580	1830345..1831136	+	792	WP_181628335.1	PhzF family phenazine biosynthesis protein	-
HVZ37_RS08585	1831617..1832009	+	393	WP_043001079.1	VOC family protein	-
HVZ37_RS08590	1832028..1832225	+	198	Protein_1679	tryptophan synthase subunit alpha	-
HVZ37_RS08595	1832606..1832863	+	258	WP_043001077.1	YjhX family toxin	Toxin
HVZ37_RS08600	1832874..1833425	+	552	WP_044258114.1	N-acetyltransferase	Antitoxin
HVZ37_RS08605	1833477..1834223	+	747	WP_181628336.1	class I SAM-dependent methyltransferase	-
HVZ37_RS08610	1834900..1835484	+	585	WP_044258110.1	hypothetical protein	-
HVZ37_RS08615	1835794..1836918	-	1125	WP_181628337.1	N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.00 Da
• Isoelectric Point: 11.1381

>T164878 WP_043001077.1 NZ_CP057150:1832606-1832863 [Citrobacter sp. RHB35-C17]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTAVECYSREGLLLADCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QPDNR

Nucleotide

• Length: 258 bp

>T164878 NZ_CP073373:c1571140-1570823 [Klebsiella sp. P1954]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20365.25 Da
• Isoelectric Point: 6.0668

>AT164878 WP_044258114.1 NZ_CP057150:1832874-1833425 [Citrobacter sp. RHB35-C17]
MTTRNFTIHITDESDTNDIREVETRAFGYSKEACLVASLLEDDTARPTLSLLARQEGNAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGRGVGGLLIRTGIEHLRSMGCQCVFVLGHATYYPRHGFEPCAGDKGFPAPYPIAEEHKACWMMQSLSA
QPFDRAGDIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT164878 NZ_CP073373:c1570830-1570543 [Klebsiella sp. P1954]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Toxin

• AlphaFold DB: A0A3S5G4N2