164869

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3855287..3855907 Replicon chromosome
Accession NZ_CP057147
Organism Citrobacter sp. RHB35-C21

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HVZ39_RS18805 Protein ID WP_002892050.1
Coordinates 3855689..3855907 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag HVZ39_RS18800 Protein ID WP_019076175.1
Coordinates 3855287..3855661 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ39_RS18790 3850434..3851627 + 1194 WP_047416860.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVZ39_RS18795 3851650..3854799 + 3150 WP_016152073.1 multidrug efflux RND transporter permease subunit -
HVZ39_RS18800 3855287..3855661 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
HVZ39_RS18805 3855689..3855907 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HVZ39_RS18810 3856088..3856639 + 552 WP_016155874.1 maltose O-acetyltransferase -
HVZ39_RS18815 3856756..3857226 + 471 WP_016152071.1 YlaC family protein -
HVZ39_RS18820 3857305..3857445 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
HVZ39_RS18825 3857447..3857707 - 261 WP_181632833.1 type B 50S ribosomal protein L31 -
HVZ39_RS18830 3857896..3859449 + 1554 WP_103928974.1 EAL domain-containing protein -
HVZ39_RS18835 3859501..3859854 - 354 WP_003831033.1 DUF1428 family protein -
HVZ39_RS18840 3859919..3860548 - 630 WP_016155872.1 membrane protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T164869 WP_002892050.1 NZ_CP057147:3855689-3855907 [Citrobacter sp. RHB35-C21]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T164869 NZ_CP073360:c4181037-4180660 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACGGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGTCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGTGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT164869 WP_019076175.1 NZ_CP057147:3855287-3855661 [Citrobacter sp. RHB35-C21]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT164869 NZ_CP073360:c4181495-4181127 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2


Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References