164859

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 997610..998264 Replicon chromosome
Accession NZ_CP057147
Organism Citrobacter sp. RHB35-C21

Toxin (Protein)


Gene name cptA Uniprot ID A0A7L6TYP6
Locus tag HVZ39_RS04930 Protein ID WP_047357821.1
Coordinates 997857..998264 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag HVZ39_RS04925 Protein ID WP_016154349.1
Coordinates 997610..997876 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ39_RS04900 992822..994255 - 1434 WP_016154353.1 6-phospho-beta-glucosidase BglA -
HVZ39_RS04905 994377..995105 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
HVZ39_RS04910 995158..995469 + 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
HVZ39_RS04915 995633..996292 + 660 WP_016154351.1 hemolysin III family protein -
HVZ39_RS04920 996372..997352 - 981 WP_016154350.1 tRNA-modifying protein YgfZ -
HVZ39_RS04925 997610..997876 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
HVZ39_RS04930 997857..998264 + 408 WP_047357821.1 protein YgfX Toxin
HVZ39_RS04935 998365..998886 - 522 WP_016154347.1 flavodoxin FldB -
HVZ39_RS04940 999000..999896 + 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
HVZ39_RS04945 999920..1000633 + 714 WP_047414418.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVZ39_RS04950 1000639..1002372 + 1734 WP_016157413.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15878.67 Da        Isoelectric Point: 11.5023

>T164859 WP_047357821.1 NZ_CP057147:997857-998264 [Citrobacter sp. RHB35-C21]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQARQG

Download         Length: 408 bp

>T164859 NZ_CP073360:1061416-1061751 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
TGTACTGATTGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT164859 WP_016154349.1 NZ_CP057147:997610-997876 [Citrobacter sp. RHB35-C21]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164859 NZ_CP073360:1061168-1061416 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6TYP6

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References