Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 827341..828094 | Replicon | chromosome |
| Accession | NZ_CP057147 | ||
| Organism | Citrobacter sp. RHB35-C21 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | R8WN26 |
| Locus tag | HVZ39_RS04065 | Protein ID | WP_016154457.1 |
| Coordinates | 827341..827718 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | HVZ39_RS04070 | Protein ID | WP_162838704.1 |
| Coordinates | 827768..828094 (-) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HVZ39_RS04040 | 822731..823792 | - | 1062 | WP_047357844.1 | nucleoid-associated protein | - |
| HVZ39_RS04045 | 824011..825258 | - | 1248 | WP_047357843.1 | integrase arm-type DNA-binding domain-containing protein | - |
| HVZ39_RS04050 | 825694..826539 | - | 846 | Protein_796 | DUF4942 domain-containing protein | - |
| HVZ39_RS04055 | 826620..826823 | - | 204 | WP_009652505.1 | DUF957 domain-containing protein | - |
| HVZ39_RS04060 | 826853..827344 | - | 492 | WP_009652438.1 | hypothetical protein | - |
| HVZ39_RS04065 | 827341..827718 | - | 378 | WP_016154457.1 | TA system toxin CbtA family protein | Toxin |
| HVZ39_RS04070 | 827768..828094 | - | 327 | WP_162838704.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HVZ39_RS04075 | 828151..828372 | - | 222 | WP_009652392.1 | DUF987 domain-containing protein | - |
| HVZ39_RS04080 | 828386..828868 | - | 483 | WP_016154455.1 | DNA repair protein RadC | - |
| HVZ39_RS04085 | 828880..829098 | - | 219 | WP_009652503.1 | hypothetical protein | - |
| HVZ39_RS04090 | 829109..829570 | - | 462 | WP_045890390.1 | antirestriction protein | - |
| HVZ39_RS04095 | 829599..829853 | - | 255 | WP_009652519.1 | hypothetical protein | - |
| HVZ39_RS04100 | 829853..830671 | - | 819 | WP_009652424.1 | DUF945 domain-containing protein | - |
| HVZ39_RS04105 | 830775..831008 | - | 234 | WP_009652474.1 | DUF905 domain-containing protein | - |
| HVZ39_RS04110 | 831064..831285 | - | 222 | WP_032950095.1 | hypothetical protein | - |
| HVZ39_RS04115 | 831367..831879 | - | 513 | WP_032950094.1 | DUF4234 domain-containing protein | - |
| HVZ39_RS04120 | 831928..832398 | - | 471 | WP_009652431.1 | hypothetical protein | - |
| HVZ39_RS04125 | 832445..832756 | - | 312 | WP_009652410.1 | hypothetical protein | - |
| HVZ39_RS04130 | 832769..833035 | - | 267 | WP_032950091.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14168.19 Da Isoelectric Point: 9.5224
>T164858 WP_016154457.1 NZ_CP057147:c827718-827341 [Citrobacter sp. RHB35-C21]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP
Download Length: 378 bp
>T164858 NZ_CP073360:924908-925315 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12079.85 Da Isoelectric Point: 6.6283
>AT164858 WP_162838704.1 NZ_CP057147:c828094-827768 [Citrobacter sp. RHB35-C21]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE
Download Length: 327 bp
>AT164858 NZ_CP073360:924661-924927 [Escherichia coli]
ATGGACATTAATAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAATAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|