Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 790471..791274 | Replicon | chromosome |
| Accession | NZ_CP057147 | ||
| Organism | Citrobacter sp. RHB35-C21 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7L6TYH6 |
| Locus tag | HVZ39_RS03875 | Protein ID | WP_047358707.1 |
| Coordinates | 790471..790851 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A7L6TXP6 |
| Locus tag | HVZ39_RS03880 | Protein ID | WP_047358708.1 |
| Coordinates | 790909..791274 (-) | Length | 122 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HVZ39_RS03855 | 786115..786711 | - | 597 | WP_181633259.1 | dienelactone hydrolase family protein | - |
| HVZ39_RS03860 | 786760..787836 | - | 1077 | WP_181633260.1 | CZB domain-containing protein | - |
| HVZ39_RS03865 | 788813..789661 | - | 849 | WP_047358705.1 | DUF4942 domain-containing protein | - |
| HVZ39_RS03870 | 789983..790474 | - | 492 | WP_047358706.1 | hypothetical protein | - |
| HVZ39_RS03875 | 790471..790851 | - | 381 | WP_047358707.1 | TA system toxin CbtA family protein | Toxin |
| HVZ39_RS03880 | 790909..791274 | - | 366 | WP_047358708.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HVZ39_RS03885 | 791296..791517 | - | 222 | WP_047358709.1 | DUF987 domain-containing protein | - |
| HVZ39_RS03890 | 791531..792010 | - | 480 | WP_047358710.1 | DNA repair protein RadC | - |
| HVZ39_RS03895 | 792023..792496 | - | 474 | WP_047358733.1 | antirestriction protein | - |
| HVZ39_RS03900 | 792765..793583 | - | 819 | WP_047358711.1 | DUF945 domain-containing protein | - |
| HVZ39_RS03905 | 793701..793952 | - | 252 | WP_047358712.1 | DUF905 family protein | - |
| HVZ39_RS03910 | 794143..794610 | - | 468 | WP_047358713.1 | hypothetical protein | - |
| HVZ39_RS03915 | 794707..795108 | - | 402 | WP_047358714.1 | hypothetical protein | - |
| HVZ39_RS03920 | 795314..796201 | - | 888 | WP_047358715.1 | 50S ribosome-binding GTPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 14216.38 Da Isoelectric Point: 10.0929
>T164857 WP_047358707.1 NZ_CP057147:c790851-790471 [Citrobacter sp. RHB35-C21]
MQTLSAIPTRKAPSHPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEKIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS
MQTLSAIPTRKAPSHPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEKIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS
Download Length: 381 bp
>T164857 NZ_CP073360:c784577-784200 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 122 a.a. Molecular weight: 13417.25 Da Isoelectric Point: 6.4780
>AT164857 WP_047358708.1 NZ_CP057147:c791274-790909 [Citrobacter sp. RHB35-C21]
MSNQLPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPALLKQLELMLVSGELN
PRHQHCVTLYAKGLTCEADSLGSHGYIYTAMYPTPDNSITR
MSNQLPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPALLKQLELMLVSGELN
PRHQHCVTLYAKGLTCEADSLGSHGYIYTAMYPTPDNSITR
Download Length: 366 bp
>AT164857 NZ_CP073360:c784998-784624 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7L6TYH6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7L6TXP6 |