Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4600427..4600962 Replicon chromosome
Accession NZ_CP057136
Organism Citrobacter freundii strain RHB36-C06

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HVZ46_RS21795 Protein ID WP_115259677.1
Coordinates 4600675..4600962 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4BKM9
Locus tag HVZ46_RS21790 Protein ID WP_006688247.1
Coordinates 4600427..4600678 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ46_RS21760 4595439..4596287 + 849 WP_135912711.1 alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ -
HVZ46_RS21765 4596284..4597042 + 759 WP_115259672.1 phosphonate C-P lyase system protein PhnK -
HVZ46_RS21770 4597151..4597831 + 681 WP_137399195.1 phosphonate C-P lyase system protein PhnL -
HVZ46_RS21775 4597828..4598964 + 1137 WP_181618046.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
HVZ46_RS21780 4598967..4599512 + 546 WP_096758664.1 ribose 1,5-bisphosphokinase -
HVZ46_RS21785 4599585..4600343 + 759 WP_181618047.1 phosphonate metabolism protein PhnP -
HVZ46_RS21790 4600427..4600678 + 252 WP_006688247.1 plasmid stabilization protein Antitoxin
HVZ46_RS21795 4600675..4600962 + 288 WP_115259677.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVZ46_RS21800 4600959..4601288 - 330 WP_096758667.1 hypothetical protein -
HVZ46_RS21805 4601357..4603621 - 2265 WP_181618048.1 hybrid sensor histidine kinase/response regulator -
HVZ46_RS21810 4603736..4605259 + 1524 WP_181618049.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11233.05 Da        Isoelectric Point: 10.3332

>T164852 WP_115259677.1 NZ_CP057136:4600675-4600962 [Citrobacter freundii]
MSYTVKFREDALKEWQKLDKTIQQQFAKELKKYGENPHVPSAKLRGIKDCYKIQLRTSRFRLVYQVIDDTLVIAVVAVGK
RERSEVYNLASERLR

Download         Length: 288 bp

>T164852 NZ_CP073360:193258-193365 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9215.53 Da        Isoelectric Point: 4.2965

>AT164852 WP_006688247.1 NZ_CP057136:4600427-4600678 [Citrobacter freundii]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Download         Length: 252 bp

>AT164852 NZ_CP073360:c193200-193146 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7X1BT32

References