Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4107967..4108612 Replicon chromosome
Accession NZ_CP057136
Organism Citrobacter freundii strain RHB36-C06

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HVZ46_RS19475 Protein ID WP_181617795.1
Coordinates 4107967..4108365 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HVZ46_RS19480 Protein ID WP_181617796.1
Coordinates 4108346..4108612 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ46_RS19455 4103915..4105648 - 1734 WP_181617791.1 single-stranded-DNA-specific exonuclease RecJ -
HVZ46_RS19460 4105654..4106367 - 714 WP_181617792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVZ46_RS19465 4106391..4107287 - 897 WP_181617793.1 site-specific tyrosine recombinase XerD -
HVZ46_RS19470 4107400..4107921 + 522 WP_181617794.1 flavodoxin FldB -
HVZ46_RS19475 4107967..4108365 - 399 WP_181617795.1 protein YgfX Toxin
HVZ46_RS19480 4108346..4108612 - 267 WP_181617796.1 FAD assembly factor SdhE Antitoxin
HVZ46_RS19485 4108868..4109848 + 981 WP_181617797.1 tRNA-modifying protein YgfZ -
HVZ46_RS19490 4109928..4110587 - 660 WP_181617798.1 hemolysin III family protein -
HVZ46_RS19495 4110750..4111061 - 312 WP_181617799.1 N(4)-acetylcytidine aminohydrolase -
HVZ46_RS19500 4111114..4111842 + 729 WP_115259901.1 MurR/RpiR family transcriptional regulator -
HVZ46_RS19505 4111963..4113396 + 1434 WP_181617800.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15634.57 Da        Isoelectric Point: 11.2851

>T164851 WP_181617795.1 NZ_CP057136:c4108365-4107967 [Citrobacter freundii]
VVQWQSDLRVSWRAQWISLLIHGLVAVLILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIVSAPWMIKTGMMLRLRSSTGKRQHLWLAADSMDDAEWRDLRRLILQQK

Download         Length: 399 bp

>T164851 NZ_CP073357:158651-158962 [Proteus terrae subsp. cibarius]
ATGCACCTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCAATATCCCAACGATTCGTTAGCCGTTCGGGCGCTGTA
CCGCTTAGTCCGCGAGACGGACTTTTCTTCTCCAGCTGAGATGCGAACGCTGATACCGAGCCTGGACAATTTTAAGTATC
GTAATAAGTGGTGGGTGTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTGAATAAACGCTTC
TATGTGAAGCACATCGCCACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10628.14 Da        Isoelectric Point: 5.1599

>AT164851 WP_181617796.1 NZ_CP057136:c4108612-4108346 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADEQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164851 NZ_CP073357:158959-159378 [Proteus terrae subsp. cibarius]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCTGTTCCCTTCCTGGGGGGCAGTTCGTC
CGAGAGCGATTACCTCGAAGCGATAGAGTTGGTGGACTATCTGATCGAAAACGACGACGAGAACCCGCTTATTGACTTCC
TGGCGAGTAAAATTGCTGACTATGAGGATAACAGCCCTCGTTTCGCTGAATTCAACAAGGCTATCGCTGAAATGCCAGTC
GGCGTTGCCCTTCTGCGCACCCTGATTGACCAGTACAGGCTGTCTTATTCTGACCTTAAGGAGGAGATCGGCTCTAAATC
GCTGGTTAGCCAGATTCTCTCTGGTCAGCGGTCACTGACAATCATGCACATTAAGGCGCTGTCTGCTCGTTTTGGTGTCA
AACCAGAGTGGTTCCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References