Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2477512..2478281 Replicon chromosome
Accession NZ_CP057136
Organism Citrobacter freundii strain RHB36-C06

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HVZ46_RS11750 Protein ID WP_181619406.1
Coordinates 2477512..2477994 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HVZ46_RS11755 Protein ID WP_168246960.1
Coordinates 2477985..2478281 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ46_RS11720 2472722..2473513 - 792 WP_181619402.1 carboxymuconolactone decarboxylase family protein -
HVZ46_RS11725 2473538..2473761 - 224 Protein_2293 hypothetical protein -
HVZ46_RS11730 2473786..2474835 - 1050 WP_181619403.1 NAD(P)-dependent alcohol dehydrogenase -
HVZ46_RS11735 2475286..2475570 + 285 Protein_2295 aldo/keto reductase -
HVZ46_RS11740 2475605..2476498 - 894 WP_181619404.1 LysR family transcriptional regulator -
HVZ46_RS11745 2476647..2477411 + 765 WP_181619405.1 SDR family oxidoreductase -
HVZ46_RS11750 2477512..2477994 - 483 WP_181619406.1 GNAT family N-acetyltransferase Toxin
HVZ46_RS11755 2477985..2478281 - 297 WP_168246960.1 DUF1778 domain-containing protein Antitoxin
HVZ46_RS11760 2478394..2480376 - 1983 WP_181619407.1 MBL fold metallo-hydrolase -
HVZ46_RS11765 2480585..2481202 - 618 WP_181619408.1 outer membrane beta-barrel protein -
HVZ46_RS11770 2481312..2481941 - 630 WP_181619409.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-148)

Antitoxin

Vibrio phage ICP1, Orf50

(17-91)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17739.36 Da        Isoelectric Point: 7.8963

>T164841 WP_181619406.1 NZ_CP057136:c2477994-2477512 [Citrobacter freundii]
MEINVTAPALLTEGHELQPFDCGNEVLNDWLRRRAIKNQYINASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDASTQGHSFGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

>T164841 NZ_CP073353:c1298-1032 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11515.11 Da        Isoelectric Point: 5.8990

>AT164841 WP_168246960.1 NZ_CP057136:c2478281-2477985 [Citrobacter freundii]
MEKLMQTSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAP
VQNVEGRQRLMDVKPEWK

Download         Length: 297 bp

>AT164841 NZ_CP073353:c1506-1282 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References