Detailed information of TA system TA164836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 557443..557959
• Replicon: chromosome
• Accession: NZ_CP057136
• Organism: Citrobacter freundii strain RHB36-C06

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5I6CHB9
• Locus tag: HVZ46_RS02770
• Protein ID: WP_000220581.1
• Coordinates: 557675..557959 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HVZ46_RS02765
• Protein ID: WP_181618514.1
• Coordinates: 557443..557685 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ46_RS02745	552458..553591	+	1134	WP_181618510.1	amidohydrolase/deacetylase family metallohydrolase	-
HVZ46_RS02750	553575..554693	+	1119	WP_181618511.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
HVZ46_RS02755	554690..555430	+	741	WP_181618512.1	KDGP aldolase family protein	-
HVZ46_RS02760	555452..557365	+	1914	WP_181618513.1	BglG family transcription antiterminator	-
HVZ46_RS02765	557443..557685	+	243	WP_181618514.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HVZ46_RS02770	557675..557959	+	285	WP_000220581.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HVZ46_RS02775	557963..558427	-	465	WP_096759476.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HVZ46_RS02780	558549..560687	-	2139	WP_181618515.1	anaerobic ribonucleoside-triphosphate reductase	-
HVZ46_RS02785	561106..562758	-	1653	WP_181618516.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10868.70 Da
• Isoelectric Point: 10.0482

>T164836 WP_000220581.1 NZ_CP057136:557675-557959 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T164836 NZ_CP073351:c4809080-4808547 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.39 Da
• Isoelectric Point: 6.3045

>AT164836 WP_181618514.1 NZ_CP057136:557443-557685 [Citrobacter freundii]
MATLNVRLDDKLKKEAYAVLDKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT164836 NZ_CP073351:c4809357-4809091 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A5I6CHB9