Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3569312..3569932 Replicon chromosome
Accession NZ_CP057125
Organism Citrobacter sp. RHB36-C18

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HVZ52_RS17105 Protein ID WP_002892050.1
Coordinates 3569714..3569932 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag HVZ52_RS17100 Protein ID WP_019076175.1
Coordinates 3569312..3569686 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ52_RS17090 3564459..3565652 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVZ52_RS17095 3565675..3568824 + 3150 WP_016152073.1 multidrug efflux RND transporter permease subunit -
HVZ52_RS17100 3569312..3569686 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
HVZ52_RS17105 3569714..3569932 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HVZ52_RS17110 3570113..3570664 + 552 WP_016155874.1 maltose O-acetyltransferase -
HVZ52_RS17115 3570781..3571251 + 471 WP_016152071.1 YlaC family protein -
HVZ52_RS17120 3571330..3571470 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
HVZ52_RS17125 3571472..3571732 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
HVZ52_RS17130 3571921..3573474 + 1554 WP_181598511.1 EAL domain-containing protein -
HVZ52_RS17135 3573526..3573879 - 354 WP_181598512.1 DUF1428 family protein -
HVZ52_RS17140 3573944..3574573 - 630 WP_016152068.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T164831 WP_002892050.1 NZ_CP057125:3569714-3569932 [Citrobacter sp. RHB36-C18]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T164831 NZ_CP073351:740280-740765 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT164831 WP_019076175.1 NZ_CP057125:3569312-3569686 [Citrobacter sp. RHB36-C18]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT164831 NZ_CP073351:739990-740283 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References