Detailed information of TA system TA164821

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2294209..2294845
• Replicon: chromosome
• Accession: NZ_CP057125
• Organism: Citrobacter sp. RHB36-C18

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2I8S6E9
• Locus tag: HVZ52_RS10910
• Protein ID: WP_049259794.1
• Coordinates: 2294209..2294397 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HVZ52_RS10915
• Protein ID: WP_131382557.1
• Coordinates: 2294429..2294845 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ52_RS10890	2290987..2291217	-	231	WP_016153158.1	DUF2554 family protein	-
HVZ52_RS10895	2291407..2291532	-	126	WP_003020230.1	DUF2474 domain-containing protein	-
HVZ52_RS10900	2291532..2292542	-	1011	WP_016153157.1	cytochrome d ubiquinol oxidase subunit II	-
HVZ52_RS10905	2292542..2293945	-	1404	WP_016153156.1	cytochrome ubiquinol oxidase subunit I	-
HVZ52_RS10910	2294209..2294397	+	189	WP_049259794.1	type II toxin-antitoxin system HicA family toxin	Toxin
HVZ52_RS10915	2294429..2294845	+	417	WP_131382557.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HVZ52_RS10920	2294938..2296347	+	1410	WP_181599228.1	PLP-dependent aminotransferase family protein	-
HVZ52_RS10925	2296677..2297822	+	1146	WP_016153154.1	ABC transporter substrate-binding protein	-
HVZ52_RS10930	2297839..2298855	+	1017	WP_053389782.1	ABC transporter ATP-binding protein	-
HVZ52_RS10935	2298856..2299800	+	945	WP_016153152.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-64)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7102.16 Da
• Isoelectric Point: 11.5775

>T164821 WP_049259794.1 NZ_CP057125:2294209-2294397 [Citrobacter sp. RHB36-C18]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Nucleotide

• Length: 189 bp

>T164821 NZ_CP073343:1477463-1477750 [Marinomonas rhizomae]
ATGTCATTAGAATTTAAACATAAATGGTTAGAATTATTTTACGAAGAAGATCAGCGTCACAGGTTGATACCTAAGAATAT
TGAAAATGCTCTCTATAGAAAGTTGGAAATTTTAGATGCGGCACTGACAGAGTCTGATTTACGGGTTCCTCCAGGTAATC
GATTTGAGCATTTAGACGGTAATCTTCAAGGCTGGTGTTCGATACGAATTAATAAACAATATCGCTTAATTTTTCAGTGG
AACCAAGGAATAGCTCTAAACACCTACCTTGACCCGCACAAATATTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15064.33 Da
• Isoelectric Point: 4.7119

>AT164821 WP_131382557.1 NZ_CP057125:2294429-2294845 [Citrobacter sp. RHB36-C18]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGTEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Nucleotide

• Length: 417 bp

>AT164821 NZ_CP073343:1477762-1478064 [Marinomonas rhizomae]
ATGCGTAAAACAAAGCGTCGCCCAGTTAGCGTTGGCGAGATGCTCAAAATTGAGTTTCTTGAGCCGATGAACATTACCTC
CAAAGCACTGGCTGATGCTATGGGAGTACATCGTAATACCGTAAGCAGCCTTATTAACGGTGGCGTGTTAACCGCACCAA
TCGCAATAAAGCTGGCAGCTGCCTTTGGCAATACACCAGAGTTTTGGTTAAACATTCAACACGCCGTCGACCTTTGGGAT
ACACGAAACCGCTATCAAGAAGAGGCGAAACAGGTTAAGCCTTTGGTTGCCGTATTCAGGTGA

Structures

Toxin

• AlphaFold DB: A0A2I8S6E9