Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1308003..1308628 Replicon chromosome
Accession NZ_CP057104
Organism Escherichia fergusonii strain RHB38-C01

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag HVZ66_RS06365 Protein ID WP_000911329.1
Coordinates 1308230..1308628 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HVZ66_RS06360 Protein ID WP_000450524.1
Coordinates 1308003..1308230 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ66_RS06335 1303806..1304276 - 471 WP_001068688.1 thioredoxin-dependent thiol peroxidase -
HVZ66_RS06340 1304276..1304848 - 573 WP_000189057.1 glycine cleavage system transcriptional repressor -
HVZ66_RS06345 1304995..1305873 + 879 WP_181591291.1 4-hydroxy-tetrahydrodipicolinate synthase -
HVZ66_RS06350 1305890..1306924 + 1035 WP_002431657.1 outer membrane protein assembly factor BamC -
HVZ66_RS06355 1307136..1307849 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HVZ66_RS06360 1308003..1308230 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HVZ66_RS06365 1308230..1308628 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
HVZ66_RS06370 1308775..1309638 + 864 WP_181591292.1 neutral zinc metallopeptidase -
HVZ66_RS06375 1309653..1311668 + 2016 WP_000829357.1 tRNA cytosine(34) acetyltransferase TmcA -
HVZ66_RS06380 1311742..1312440 + 699 WP_000679829.1 esterase -
HVZ66_RS06385 1312533..1312733 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T164791 WP_000911329.1 NZ_CP057104:1308230-1308628 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T164791 NZ_CP073286:c102788-102318 [Klebsiella pneumoniae subsp. ozaenae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT164791 WP_000450524.1 NZ_CP057104:1308003-1308230 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT164791 NZ_CP073286:c103228-102785 [Klebsiella pneumoniae subsp. ozaenae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References