Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 433472..433994 Replicon chromosome
Accession NZ_CP057104
Organism Escherichia fergusonii strain RHB38-C01

Toxin (Protein)


Gene name relE Uniprot ID A0A7W3EN85
Locus tag HVZ66_RS02125 Protein ID WP_046083069.1
Coordinates 433704..433994 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag HVZ66_RS02120 Protein ID WP_000212715.1
Coordinates 433472..433714 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ66_RS02100 429389..430762 + 1374 WP_181591106.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
HVZ66_RS02105 430845..431396 - 552 WP_000166270.1 ribosome-associated protein -
HVZ66_RS02110 431490..432842 + 1353 WP_001162171.1 metalloprotease PmbA -
HVZ66_RS02115 432895..433281 + 387 WP_001232246.1 cytochrome b562 -
HVZ66_RS02120 433472..433714 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HVZ66_RS02125 433704..433994 + 291 WP_046083069.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVZ66_RS02130 433995..434459 - 465 WP_001106235.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HVZ66_RS02135 434644..436782 - 2139 WP_000187805.1 anaerobic ribonucleoside-triphosphate reductase -
HVZ66_RS02140 437176..438831 - 1656 WP_181591107.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11323.22 Da        Isoelectric Point: 10.3007

>T164784 WP_046083069.1 NZ_CP057104:433704-433994 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVTVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRRVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T164784 NZ_CP073285:2082098-2082200 [Klebsiella pneumoniae subsp. ozaenae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT164784 WP_000212715.1 NZ_CP057104:433472-433714 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT164784 NZ_CP073285:c2082207-2082062 [Klebsiella pneumoniae subsp. ozaenae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3EN85

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References