Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 197188..198231 Replicon chromosome
Accession NZ_CP057104
Organism Escherichia fergusonii strain RHB38-C01

Toxin (Protein)


Gene name panT Uniprot ID A0A7Z8DXL5
Locus tag HVZ66_RS00940 Protein ID WP_021563277.1
Coordinates 197683..198231 (+) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag HVZ66_RS00935 Protein ID WP_000287252.1
Coordinates 197188..197661 (+) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ66_RS00910 193265..193633 + 369 WP_000002903.1 diacylglycerol kinase -
HVZ66_RS00915 193743..194351 + 609 WP_000646099.1 transcriptional repressor LexA -
HVZ66_RS00920 194424..195749 + 1326 WP_181591071.1 MATE family efflux transporter DinF -
HVZ66_RS00925 195881..196090 + 210 WP_001030605.1 CsbD family protein -
HVZ66_RS00930 196141..196656 - 516 WP_000426182.1 zinc uptake transcriptional repressor Zur -
HVZ66_RS00935 197188..197661 + 474 WP_000287252.1 SocA family protein Antitoxin
HVZ66_RS00940 197683..198231 + 549 WP_021563277.1 hypothetical protein Toxin
HVZ66_RS00945 198265..198537 - 273 WP_001093913.1 pyocin activator PrtN family protein -
HVZ66_RS00950 198574..199146 - 573 WP_001061343.1 3'-5' exoribonuclease -
HVZ66_RS00955 199146..199955 - 810 WP_000206745.1 hypothetical protein -
HVZ66_RS00960 199955..200317 - 363 WP_021563278.1 phage protein -
HVZ66_RS00965 200308..200844 - 537 WP_000008210.1 5'-deoxynucleotidase -
HVZ66_RS00970 200972..201796 - 825 WP_000081280.1 DUF2303 family protein -
HVZ66_RS00975 201862..202224 - 363 WP_000135680.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 190156..248583 58427


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 19952.40 Da        Isoelectric Point: 4.5662

>T164783 WP_021563277.1 NZ_CP057104:197683-198231 [Escherichia fergusonii]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQVFKSAFEPSNHESDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T164783 NZ_CP073285:797924-798334 [Klebsiella pneumoniae subsp. ozaenae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT164783 WP_000287252.1 NZ_CP057104:197188-197661 [Escherichia fergusonii]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT164783 NZ_CP073285:797677-797943 [Klebsiella pneumoniae subsp. ozaenae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z8DXL5

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References