Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3628107..3628761 Replicon chromosome
Accession NZ_CP057101
Organism Escherichia fergusonii strain RHB38-C04

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag HVZ67_RS17455 Protein ID WP_000244781.1
Coordinates 3628107..3628514 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HVZ67_RS17460 Protein ID WP_000354046.1
Coordinates 3628495..3628761 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ67_RS17435 3624064..3625797 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
HVZ67_RS17440 3625803..3626513 - 711 WP_046076902.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVZ67_RS17445 3626538..3627434 - 897 WP_046076901.1 site-specific tyrosine recombinase XerD -
HVZ67_RS17450 3627546..3628067 + 522 WP_001055874.1 flavodoxin FldB -
HVZ67_RS17455 3628107..3628514 - 408 WP_000244781.1 protein YgfX Toxin
HVZ67_RS17460 3628495..3628761 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HVZ67_RS17465 3629013..3629993 + 981 WP_181576219.1 tRNA-modifying protein YgfZ -
HVZ67_RS17470 3630070..3630729 - 660 WP_000250283.1 hemolysin III family protein -
HVZ67_RS17475 3630893..3631204 - 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
HVZ67_RS17480 3631249..3632682 + 1434 WP_046076973.1 6-phospho-beta-glucosidase BglA -
HVZ67_RS17485 3632730..3633623 - 894 WP_125282718.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T164780 WP_000244781.1 NZ_CP057101:c3628514-3628107 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T164780 NZ_CP057101:c3628514-3628107 [Escherichia fergusonii]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGTTAAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACTTGTGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT164780 WP_000354046.1 NZ_CP057101:c3628761-3628495 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164780 NZ_CP057101:c3628761-3628495 [Escherichia fergusonii]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGTGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References