Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3459640..3460474 Replicon chromosome
Accession NZ_CP057101
Organism Escherichia fergusonii strain RHB38-C04

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2X7CAN1
Locus tag HVZ67_RS16600 Protein ID WP_039025883.1
Coordinates 3459640..3460017 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2X5LBZ2
Locus tag HVZ67_RS16605 Protein ID WP_039025882.1
Coordinates 3460106..3460474 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ67_RS16575 3455605..3455763 - 159 WP_000788777.1 hypothetical protein -
HVZ67_RS16580 3456581..3457900 + 1320 WP_105284452.1 site-specific integrase -
HVZ67_RS16585 3457993..3458841 - 849 WP_039025884.1 DUF4942 domain-containing protein -
HVZ67_RS16590 3458938..3459135 - 198 WP_000772024.1 DUF957 domain-containing protein -
HVZ67_RS16595 3459155..3459643 - 489 Protein_3234 hypothetical protein -
HVZ67_RS16600 3459640..3460017 - 378 WP_039025883.1 type IV toxin-antitoxin system toxin CbtA Toxin
HVZ67_RS16605 3460106..3460474 - 369 WP_039025882.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HVZ67_RS16610 3460524..3461168 - 645 WP_039025881.1 hypothetical protein -
HVZ67_RS16615 3461183..3461404 - 222 WP_000692312.1 DUF987 domain-containing protein -
HVZ67_RS16620 3461473..3461949 - 477 WP_001186745.1 RadC family protein -
HVZ67_RS16625 3461964..3462449 - 486 WP_000214316.1 antirestriction protein -
HVZ67_RS16630 3462540..3463358 - 819 WP_181576213.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3443766..3462449 18683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14176.22 Da        Isoelectric Point: 7.8523

>T164779 WP_039025883.1 NZ_CP057101:c3460017-3459640 [Escherichia fergusonii]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T164779 NZ_CP073283:c1862767-1862540 [Bifidobacterium longum subsp. infantis]
ATGAAGAAGCTGGATCGTAATGTTGCCAAGAGAATCATCGCAAAGCTTAGGGAAATTTCACAGTTGGAAGATCCGAGAAG
CACCGGCAAGGCTCTTGCCGGTAATCTGGCAGGGCTGTGGCGTTACCGTGTCGGGGACTATCGTATCGTGTGCGATATAG
AGGATGAGGTTCTGCTGATTCTTGTGATTGATGTCGCGCACAGGAGCAAGGTGTACAAGCGTTGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13792.52 Da        Isoelectric Point: 5.9582

>AT164779 WP_039025882.1 NZ_CP057101:c3460474-3460106 [Escherichia fergusonii]
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT164779 NZ_CP073283:c1863029-1862793 [Bifidobacterium longum subsp. infantis]
ATGGCCACGGTTACTGCAGCATTAAGGATGCCTGTCGAATTGGCGGCTCGTTACGATTGTCTGGCGAAAGCGACTGGTCG
TACGAAGACGTTTTACATGAACGAAGCCCTTACCGAATCGATCGATAGGTTTGAGTATGAATACGGCATTATGAAAAAGG
TCGAGGATTGGCGTGCCGGCAGACTCGAAACCGTGACGCTCGACGAGCTGGAGGAAAGCCTTGGCTTGGAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X7CAN1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X5LBZ2

References