Detailed information of TA system TA164778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3315047..3315666
• Replicon: chromosome
• Accession: NZ_CP057101
• Organism: Escherichia fergusonii strain RHB38-C04

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: HVZ67_RS15915
• Protein ID: WP_001280991.1
• Coordinates: 3315448..3315666 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: HVZ67_RS15910
• Protein ID: WP_104917851.1
• Coordinates: 3315047..3315421 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ67_RS15900	3310179..3311372	+	1194	WP_002431407.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
HVZ67_RS15905	3311395..3314544	+	3150	WP_001132493.1	multidrug efflux RND transporter permease subunit	-
HVZ67_RS15910	3315047..3315421	+	375	WP_104917851.1	Hha toxicity modulator TomB	Antitoxin
HVZ67_RS15915	3315448..3315666	+	219	WP_001280991.1	hemolysin expression modulator Hha	Toxin
HVZ67_RS15920	3316163..3316633	+	471	WP_002431406.1	YlaC family protein	-
HVZ67_RS15925	3316772..3318322	+	1551	WP_181576209.1	EAL domain-containing protein	-
HVZ67_RS15930	3318364..3318717	-	354	WP_000878140.1	DUF1428 domain-containing protein	-
HVZ67_RS15940	3319096..3319407	+	312	WP_000409911.1	MGMT family protein	-
HVZ67_RS15945	3319438..3320010	-	573	WP_000779831.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T164778 WP_001280991.1 NZ_CP057101:3315448-3315666 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T164778 NZ_CP073283:1337909-1338232 [Bifidobacterium longum subsp. infantis]
ATGAAACGAGGTGAGATTTGGACGTTGCAGGCCGATGGCTACGCCAGCAAGCCACGGCCGGTTGTCATCGTGCAGAGCGA
TGCCGTCGATCGGTTCGATTCCGTCATCACTTGTCTGCTGACCTCATACGATTCCTCCGACATCGACACGCGGGTCCGAT
TGGAACCAAGTCCGGAGAACGGCCTGAACAAAGTGAGTTACGTGATGACGGACAAGATCGTCACCGTCGACCGCAAACTG
CTGGGATACCAAGTCGGCGTGGTTGATGATGCAGCCATGGCGAATATCGGCCGTCAGCTCATGCGGGTTCTAGGTTTGCT
GTGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14511.31 Da
• Isoelectric Point: 4.8989

>AT164778 WP_104917851.1 NZ_CP057101:3315047-3315421 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT164778 NZ_CP073283:1337677-1337922 [Bifidobacterium longum subsp. infantis]
ATGAGCATGCAGATTGCCACGCGAGTTGATGACGAGCAGGCTGCGTTGTTTAAGGAGACGACCCGACAGCTGGGCATCAC
CCCGGCCGATGCCCTGCGTATGTTCATCAGCGCGTTCAATGATTACCGTGGGTTCCCCTATGAGGTGCGTTTGCCACGAA
ATGACGTGGAGCCGTTTGCGTCCGAGCGGGACGCTACTGAGTATGCCAGTCGTCTCGCCTTGAGGATGTCCGATGAAACG
AGGTGA

Structures

Toxin

• PDB: 4ICG