Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4829483..4831164 Replicon chromosome
Accession NZ_CP057099
Organism Klebsiella pneumoniae strain RHB38-C06

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag HVZ68_RS23720 Protein ID WP_019724882.1
Coordinates 4829483..4830400 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag HVZ68_RS23725 Protein ID WP_004177809.1
Coordinates 4830406..4831164 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ68_RS23700 4824789..4826309 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
HVZ68_RS23705 4826306..4827304 + 999 WP_002885172.1 ribose ABC transporter permease -
HVZ68_RS23710 4827335..4828276 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
HVZ68_RS23715 4828351..4829358 + 1008 WP_015959270.1 carbohydrate kinase family protein -
HVZ68_RS23720 4829483..4830400 - 918 WP_019724882.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
HVZ68_RS23725 4830406..4831164 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
HVZ68_RS23730 4831250..4831978 - 729 WP_002885152.1 response regulator transcription factor -
HVZ68_RS23735 4832251..4834398 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
HVZ68_RS23740 4834628..4835314 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T164762 WP_019724882.1 NZ_CP057099:c4830400-4829483 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T164762 NZ_CP073262:c1436191-1435904 [Duffyella gerundensis]
ATGGGCTATACAATTAAAATCAGGGAAGAGGCGCTGAAAGAATGGAATGGGCTCGACAGCATCATTCGTGAGCAGTTTAA
AAAGAAGCTCAAAAAGCCGCTTGAAAATCCGCACATCCCTGCAGCACGGTTATCCGGTATGCCAGACTGCTATAAAATCA
ATCTCAGGGCATCCGGCTTCAGGTTGGTTTATCAGGTGATGGATGATGTGCTGATTGTCGCTGTGGTCGCGGTAGGTAAA
CGAGAGCGTAGCCAGGCCTATAAGCTGGCGAGCGAAAGATTACGTTGA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT164762 WP_004177809.1 NZ_CP057099:c4831164-4830406 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT164762 NZ_CP073262:c1436439-1436197 [Duffyella gerundensis]
ATGGCTAATCTTATCCTTAGTGATACCAGCGCGAGTGTCAGCGAGCTGAAAAAAAAACCCATGGCTACCGTTGAAGCCGG
TGCCGGCATGCCAGTGACGATTCTTAACCGAAACCAACCCGTATTCTATTGTGTGCCTGCGCATCTGTACGAAAAAATGC
TTGAAATCATTGACGATCAGGAGCTGGCAACGCTAGTAAAAGCACGCGAAAATCAGCCTTTGCTTGATCTGGATTTGGAC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YLF8

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References