Detailed information of TA system TA164758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2639539..2641127
• Replicon: chromosome
• Accession: NZ_CP057099
• Organism: Klebsiella pneumoniae strain RHB38-C06

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A486RAG1
• Locus tag: HVZ68_RS13145
• Protein ID: WP_016946382.1
• Coordinates: 2639539..2640861 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: HVZ68_RS13150
• Protein ID: WP_002904790.1
• Coordinates: 2640861..2641127 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ68_RS13130	2634595..2637096	+	2502	WP_023282574.1	fimbrial biogenesis outer membrane usher protein	-
HVZ68_RS13135	2637084..2638088	+	1005	WP_016946380.1	type 1 fimbrial protein	-
HVZ68_RS13140	2638230..2639522	+	1293	WP_016946381.1	glycoside hydrolase family 10 protein	-
HVZ68_RS13145	2639539..2640861	-	1323	WP_016946382.1	type II toxin-antitoxin system HipA family toxin	Toxin
HVZ68_RS13150	2640861..2641127	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HVZ68_RS13155	2641514..2641840	-	327	WP_004215084.1	hydroxyisourate hydrolase	-
HVZ68_RS13160	2641837..2642337	-	501	WP_023282573.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HVZ68_RS13165	2642315..2643694	-	1380	WP_004184021.1	purine permease	-
HVZ68_RS13170	2644040..2645194	+	1155	WP_023282572.1	FAD-dependent urate hydroxylase HpxO	-
HVZ68_RS13175	2645175..2646098	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49125.44 Da
• Isoelectric Point: 7.5358

>T164758 WP_016946382.1 NZ_CP057099:c2640861-2639539 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T164758 NZ_CP073248:1725936-1726319 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCACGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT164758 WP_002904790.1 NZ_CP057099:c2641127-2640861 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT164758 NZ_CP073248:1725718-1725939 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCACTGACAAATCGATGA

Structures

Toxin

• AlphaFold DB: A0A486RAG1

Antitoxin

• AlphaFold DB: A0A0H3GXD8