Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 781030..781687 Replicon chromosome
Accession NZ_CP057099
Organism Klebsiella pneumoniae strain RHB38-C06

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HVZ68_RS03870 Protein ID WP_002916310.1
Coordinates 781277..781687 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HVZ68_RS03865 Protein ID WP_002916312.1
Coordinates 781030..781296 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ68_RS03840 776186..777619 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
HVZ68_RS03845 777738..778466 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HVZ68_RS03850 778516..778827 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HVZ68_RS03855 778991..779650 + 660 WP_002916317.1 hemolysin III family protein -
HVZ68_RS03860 779801..780784 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HVZ68_RS03865 781030..781296 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HVZ68_RS03870 781277..781687 + 411 WP_002916310.1 protein YgfX Toxin
HVZ68_RS03875 781694..782215 - 522 WP_004144730.1 flavodoxin FldB -
HVZ68_RS03880 782316..783212 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HVZ68_RS03885 783235..783948 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVZ68_RS03890 783954..785687 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T164749 WP_002916310.1 NZ_CP057099:781277-781687 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T164749 NZ_CP073245:c567675-567256 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGTGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAAAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACATAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATATCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT164749 WP_002916312.1 NZ_CP057099:781030-781296 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164749 NZ_CP073245:c567905-567672 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGACAGTGATTTCCTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References