Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3750431..3751085 Replicon chromosome
Accession NZ_CP057093
Organism Escherichia fergusonii strain RHB38-C07

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HVZ69_RS18275 Protein ID WP_181587862.1
Coordinates 3750431..3750838 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HVZ69_RS18280 Protein ID WP_000354046.1
Coordinates 3750819..3751085 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ69_RS18255 3746388..3748121 - 1734 WP_181587860.1 single-stranded-DNA-specific exonuclease RecJ -
HVZ69_RS18260 3748127..3748837 - 711 WP_181587861.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVZ69_RS18265 3748862..3749758 - 897 WP_000806645.1 site-specific tyrosine recombinase XerD -
HVZ69_RS18270 3749870..3750391 + 522 WP_001055874.1 flavodoxin FldB -
HVZ69_RS18275 3750431..3750838 - 408 WP_181587862.1 protein YgfX Toxin
HVZ69_RS18280 3750819..3751085 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HVZ69_RS18285 3751337..3752317 + 981 WP_181587863.1 tRNA-modifying protein YgfZ -
HVZ69_RS18290 3752394..3753053 - 660 WP_000250283.1 hemolysin III family protein -
HVZ69_RS18295 3753217..3753528 - 312 WP_104917535.1 N(4)-acetylcytidine aminohydrolase -
HVZ69_RS18300 3753573..3755006 + 1434 WP_181587864.1 6-phospho-beta-glucosidase BglA -
HVZ69_RS18305 3755054..3755947 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16092.07 Da        Isoelectric Point: 11.2511

>T164735 WP_181587862.1 NZ_CP057093:c3750838-3750431 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLIAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T164735 NZ_CP073236:5108181-5108438 [Klebsiella pasteurii]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACGTTCGCGATACATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAACAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT164735 WP_000354046.1 NZ_CP057093:c3751085-3750819 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT164735 NZ_CP073236:5108449-5109000 [Klebsiella pasteurii]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCAATGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCTCTTTGCTCAACGATGAGAGCGCCTGCCCGACGTTATCGCTGCTGGCCA
GGCATAACGGAAAGGCGGTTGGGCATATTTTATTCACCCGGGCGATGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGCGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCCATAGGAAGCCAGACGGTATTTGTTCTGGGCCACGCCACTTACTACCCCAGGCACGGGTTTGAGCCATGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGAGGCGCATAAAGCCTGCTGGATGCTACAGCGGCTTTCGTCT
CAGCCGCTGGGGCGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References